I'll post market design related news and items about repugnant markets. See also my Stanford profile. I have a general-interest book on market design: Who Gets What--and Why The subtitle is "The new economics of matchmaking and market design."
Yesterday was Loving Day, the anniversary of the Supreme Court decision on June 12, 1967 in the case of Loving v. Virginia, that bans on interracial marriage were unconstitutional.
"When they married in Oakland in 1950, mixed-race marriage had just become legal in California, the result of a lawsuit that reached the State Supreme Court. They are among the oldest living interracial couples legally married in the United States. It would be nearly two decades before all couples like them across the country were allowed to marry.
On Monday, they will mark the 50th anniversary of Loving v. Virginia, the United States Supreme Court case that overturned antimiscegenation laws nationwide. Mildred and Richard Loving, a black woman and a white man, had been sentenced to a year in a Virginia prison for marrying each other. The case would serve as a basis for the Supreme Court decision allowing same-sex marriage."
Transplantation would be a lot less hectic if organs could be preserved. Here's a 42-author paper (the biggest coauthorship I've been involved in) that discusses some of the possibilities.
The promise of organ and tissue preservation to transform medicine
Sebastian Giwa, Jedediah K Lewis, Luis Alvarez, Robert Langer, Alvin E Roth, George M Church, James F Markmann, David H Sachs, Anil Chandraker, Jason A Wertheim, Martine Rothblatt, Edward S Boyden, Elling Eidbo, W P Andrew Lee, Bohdan Pomahac, Gerald Brandacher, David M Weinstock, Gloria Elliott, David Nelson, Jason P Acker, Korkut Uygun, Boris Schmalz, Brad P Weegman, Alessandro Tocchio, Greg M Fahy, Kenneth B Storey, Boris Rubinsky, John Bischof, Janet A W Elliott, Teresa K Woodruff, G John Morris, Utkan Demirci, Kelvin G M Brockbank, Erik J Woods, Robert N Ben, John G Baust, Dayong Gao, Barry Fuller, Yoed Rabin, David C Kravitz, Michael J Taylor & Mehmet Toner
Nature Biotechnology 35, 530–542 (2017) doi:10.1038/nbt.3889
Published online 07 June 2017
Abstract: The ability to replace organs and tissues on demand could save or improve millions of lives each year globally and create public health benefits on par with curing cancer. Unmet needs for organ and tissue preservation place enormous logistical limitations on transplantation, regenerative medicine, drug discovery, and a variety of rapidly advancing areas spanning biomedicine. A growing coalition of researchers, clinicians, advocacy organizations, academic institutions, and other stakeholders has assembled to address the unmet need for preservation advances, outlining remaining challenges and identifying areas of underinvestment and untapped opportunities. Meanwhile, recent discoveries provide proofs of principle for breakthroughs in a family of research areas surrounding biopreservation. These developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research. Capitalizing on these opportunities will require engagement across many research areas and stakeholder groups. A coordinated effort is needed to expedite preservation advances that can transform several areas of medicine and medical science.
When I was in Trento I was approached by a team from an Italian-Californian startup that is trying to develop a portable hemodialysis system that could fit in the overhead compartment on a plane, or could allow a van to become a mobile dialysis provider. Here's their webpage: EasyDial, and good luck to them.
FutureEd is a new(ish) educational think tank at Georgetown, founded by veteran Ed writer Thomas Toch.
"FutureEd is an independent, solution-oriented think tank at Georgetown University's McCourt School of Public Policy. We are committed to bringing fresh energy to the causes of excellence, equity, and efficiency in K-12 and higher education on behalf of the nation's disadvantaged students. As a nonpartisan, public-facing organization, we work to produce clear, compelling analysis on key education issues for policymakers, practitioners, the media, and other key education change agents and influencers at the federal, state, and local levels—promoting smart policymaking in a complex and fast-changing educational landscape."
During the AEA meetings in January, the Lindau festival recorded some short video snippets. Here's an edited collection of words of advice for young economists from eight old ones...
The Mercury News brings us up to date on California's right to die law California’s right-to-die law: Patients struggling to find doctors who will help
"It’s been nearly a year since California began allowing terminally ill residents to end their lives with the help of a physician. And for Ray Perman, the right-to-die law worked exactly as lawmakers intended.
"On Feb. 4, as his family gathered around his bed, the 64-year-old Piedmont resident ingested a lethal dose of sedatives and passed away peacefully — in his own home, on his own terms — after years of battling cancer.
...
"But for many other Californians, the End of Life Option Act — which took effect June 9, 2016 — has led to a desperate race against time. Frustrated and unable to care for themselves, these terminal patients have frantically searched to find the required two physicians they must work with to terminate their lives.
"Add in the law’s mandated 15-day waiting period between the two oral requests they must make to the two doctors for the medication and it’s often too late to follow through with their plans.
...
“At this stage in the law, it’s a little bit of a hard road,’’ said Judith Geisser, a retired attorney who lives in Oakland.
"Geisser watched as her dying brother’s oncologists — one in Santa Rosa who had treated him for colorectal cancer, another in San Francisco who had diagnosed his subsequent brain cancer — politely declined to help him die, or even refer him to colleagues who would.
...
"Geisser offers this advice to anyone who wants to take advantage of the law: Start your search for the two physicians sooner rather than later.
“When you’re not healthy, and not at your best, that’s not the time to manage the path through this law,’’ said Geisser, who was forced to scramble to find a physician to help her 67-year-old brother Pat fulfill his last wish.
...
"Opponents of the law, including Californians Against Assisted Suicide, have watched its implementation with dread and cite a litany of concerns.
“It’s bad policy,’’ said the group’s spokesman, Tim Rosales.
"He said there are too many loopholes in the law, including the fact that the law doesn’t require those patients receiving lethal prescriptions to get any type of counseling beforehand from a mental health professional. In addition, he said, “there’s no requirement that somebody who stood to gain financially from that individual’s passing could not be involved in the process.’’
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see my earlier post:
"Alexander Peysakhovich is technically a behavioral economist, but he bristles a bit at being defined that narrowly. He's a scientist in Facebook's artificial intelligence research lab, as well as a prolific scholar, having posted five papers in 2016 alone. He has a Ph.D. from Harvard University, where he won a teaching award, and has published articles in the New York Times, Wired, and several prestigious academic journals.
Despite these accomplishments, Peysakhovich says, "I'm most proud of the fact that I've managed to learn enough of lots of different fields so that I can work on problems that I'm interested in using those methods. I've co-authored with economists, game theorists, computer scientists, neuroscientists, psychologists, evolutionary biologists, and statisticians."
Peysakhovich's interdisciplinary work is driven by his deep interest in understanding decision-making—both human and machine—and by his desire to figure out how artificial intelligence can improve our decision-making processes. He builds tools that help people make better choices, and machines that can turn data into, as he puts it, "not just correlations but actual causal relationships."
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The photo in the article comes from Alex's dissertation defense at Harvard (in 2012, when I was already at Stanford, hence that particular picture...)
When I was in Trento, I participated in a panel on markets for human organs, and had the chance to ask Dr. Ignazio Marino about the recent
Vatican statement on organ transplantation, which I pointed out seemed to conflate killing prisoners for their organs with much more ordinary attempts to increase voluntary organ donation. Dr Marino replied that this had been part of the diplomacy involved with the Chinese delegation.
Here's an article about the backstory to some of that diplomacy, and the role played by my old friend Frank Delmonico
"A controversy was brewing. Delmonico, a leading voice on ethical organ transplantation, had planned a February 2017 summit in Rome for representatives of more than 40 countries to discuss the ethics of transplanting organs and to sign a pledge to uphold high standards.
"But there was a hitch: A key invitee to the forum was Dr. Jiefu Huang, who has led reform of China’s organ donation practices. Critics, including some in the Vatican, wanted at the summit no representatives of China, which for years sold and transplanted organs from executed prisoners.
"Delmonico, however, saw the Chinese presence as a good thing. It was “an opportunity for them to proclaim a new day and be accountable” that the practice has stopped, he said. In fact, some of the Chinese old guard have attacked Huang because of his efforts to stamp out unethical and corrupt methods of obtaining organs.
...
"Pope Francis did not attend, but Marcelo Sánchez Sorondo, the chancellor of the Pontifical Academy of Sciences did. In a significant development, China signed the summit’s statement condemning the use of organs from prisoners and advocating the creation of national laws to prosecute transplant-related crimes. Beijing’s two delegates were joined by 75 other signatories representing more than 50 institutions and more than 40 nations at the conference. Delmonico called it a “seminal event” in the fight for global reform."
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I hope that this effort at diplomacy, aimed at ending the practice of using executions as the primary source of organs in China, will not be a source of confusion regarding attempts to increase the availability of organ transplants by ethical means.
I'm back home, after two exciting days in Trento (and two long days of travel). There are a bunch of videos, and some press coverage, for those of you who speak Italian or like to use Google Translate.
You can hear the videos in English if you click on the URL, then start the video by clicking on the arrow in the middle of the screen, and then clicking on the gear icon in the lower right hand corner to select English. (It isn't enough to just click on the English symbol in the upper right...)
Here's a 1 minute video in English, a sort of trailer for my talk on global kidney exchange:
The questions and answer period begins at minute 44, with a question by the eminent transplant nephrologist Giuseppe Remuzzi about his concern (which he mentions is also Frank Delmonico's) that the Philippines and Mexico, where Global Kidney Exchange has begun, are places where there is not only transplant infrastructure, but also illegal, black market organ trafficking. He ends by saying that he remains to be (but hopes to be) convinced that GKE is a good idea.
My answer begins at minute 46:40.
I replied in part "One reason people get kidneys in illegal black markets is that they don't have better opportunities. We would like to provide them with a better opportunity..."
Oggi alle 16 l'inaugurazione al Palazzo della Provincia. Alle 18 al teatro Sociale l'apertura è affidata al Nobel Alvin Roth. Da domani anche la nostra emittente sarà in piazza S.Maria Maggiore
Business Insider Italia has an interview with Ignazio Marino: Ignazio Marino: “Il mercato nero dei trapianti si può mettere all’angolo salvando molte vite”
(Google translate doesn't seem to do a good job turning it into English, but the very last sentence is
"Quello che ci ha mostrato Roth è un sistema trasparente e può togliere ossigeno ai trafficanti”.
GT renders that as 'What showed us Roth is a transparent system and can remove oxygen to "traffickers.'
Here's a story with an inflammatory headline but a reasonable account, as near as I can tell from Google Translate: L'economista che vuole legalizzare il traffico d'organi per salvare ricchi (e poveri) del mondo
"The economist who wants to legalize organ trafficking to save the rich (and poor) in the world
"In the US there are 100 thousand people on the waiting list for a kidney transplant but only 12 thousand a year. In the Philippines you do not pay you dialysis. In China they were using executed prisoners as donors. The organs of the problem is global and the Nobel Alvin Roth has the answer (maybe): scambiamoceli among us"
by Francesco Floris, June 7, 2017
"SPRINGFIELD, Ill., May 16, 2017 /PRNewswire-USNewswire/ -- In an overwhelming bipartisan show of support, the Illinois State Senate unanimously passed (53-0) HB 1805, the "Drive for Life Bill". Supported by the Secretary of State, a coalition of state legislators and Gift of Hope Organ and Tissue Donor Network and Mid-America Transplant, this critical legislation amends Section 6-117 of the Illinois Vehicle Code to allow Illinois residents 16 and older to join the organ donor registry. The bill will now be presented to Illinois Governor Bruce Rauner to sign into law.
...
"Illinois is one of only three states in the union that does not allow 16- and 17-year-olds to register their wishes to become organ donors. The "Drive for Life Act" would ensure all residents 16 and older may choose to officially join the First-Person Authorization Registry. While the law gives 16- and 17-year-olds the right to express their wishes, parents and legal guardians will maintain the right to give or revoke consent until the registered donors turn 18-years-old."
Illegal markets are hard to close down, and that goes double for advertisements for illegal markets, in which free speech issues and third-party issues ('we just post ads, we don't vouch for the advertisers') may also be in play.
"It’s tough getting a consensus on anything these days, but child sex abuse and human trafficking are generally considered indefensible crimes. So who’s defending them?
According to “I Am Jane Doe,” that would be Google. And Microsoft. And Facebook. And Yahoo.
Directed by Mary Mazzio (“Lemonade Stories,” “Underwater Dreams”) and coming to Netflix May 26 after a theatrical run earlier this year, the documentary advocates for victims of online trafficking while taking principal aim at the classified-ad website Backpage.com, a notorious venue for sex ads and transactions, many involving children. In its indictment of Backpage.com and the tech companies that are indirectly supporting the website, the film may also give a public relations boost to members of Congress working to tighten laws surrounding Internet liability.
...
According to Section 230 of the 1996 Communications Decency Act, online service providers cannot be held liable for third-party content. But that means if someone sells a 13-year-old on its pages, Backpage says, it isn’t responsible. And so far, court after court has agreed — to the relief of First Amendment absolutists, and the Silicon Valley companies mentioned above, which support, financially, organizations defending Backpage’s position.
...
Backpage was once part of Village Voice Media and is now owned by a Dutch firm, although founders Michael Lacey and Jim Larkin and chief executive Carl Ferrer have been named in the suits. “I Am Jane Doe” picks up the Backpage saga in 2010 with lawsuits filed by girls who were trafficked on its pages, and continues through a Senate subcommittee investigation led by Sen. Rob Portman (R-Ohio) in January, as well as criminal charges of pimping and money laundering brought by then-California Attorney General Kamala D. Harris, now a Democratic senator. It also focuses on the effort that has thus far made the most headway — a civil suit that continues in Washington state, piloted by lawyer Erik Bauer. Backpage will try to get that case dismissed during a summary judgment hearing Wednesday. A jury trial is scheduled for Oct. 9.
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In the meantime, the closing of Backpage's "adult" ads section hasn't shut down other ads:
"In the midst of a Senate investigation, a federal grand jury inquiry in Arizona, two federal lawsuits and criminal charges in California accusing Backpage’s operators of pimping children, the website abruptly bowed to pressure in January and replaced its sex ads with the word “Censored” in red.
Even so, Tiffany — a street name — did not stop using the site, she said. Instead, her ads moved to Backpage’s dating section. “New in town,” read a recent one, using words that have become code for selling sex. “Looking for someone to hang out with.” Other recent dating ads listed one female as “100% young” and suggested that “oh daddy can i be your candy.”
In the fight against child sex trafficking, shutting down an epicenter like Backpage was a major victory, but one against a relentless foe that quickly unfurled new tentacles. The demise of Backpage’s adult ads undermined the trade, but it also illustrated how difficult it is to stamp out the practice of selling children for sex. The crime is rarely punished with the full force of the law — charges like rape or statutory rape — officials say; in many places it leads to just a citation, instead of an arrest.
For Tiffany, 18, the demise of Backpage’s adult listings has made things far more unpredictable — and dangerous, she said. The old ads allowed her to try to vet customers by contacting them before meetings, via phone or text message. With far fewer inquiries from the dating ads, she said, her first encounters with men now take place more often on the street as she gets into cars in red light districts around the Bay Area."
"An Italian court’s decision to recognize two homosexual men as the fathers of twin children has exposed confusion and a deep divide in the country over parenting rights of same-sex couples.
It was disclosed earlier this week that a court in the northern Italian city of Trento granted the men full rights as parents to their six-year-old twins, who were born in Canada through surrogacy.
The gay community hailed the decision—the first to accord full parental rights to a non-biological father—as historic in a country that last year became one of the last in Europe to approve civil unions for gay couples. But the ruling kicked up controversy right away, with the head of the main group opposing the civil-unions bill saying it marked a “sad day for Italy.”
...
"The 2016 legislation approving civil unions stopped short of addressing broader questions of parental rights and other family law issues for same-sex couples. Political opposition was so fierce that lawmakers scotched any reference to adoption or parental rights to get the bill passed. As a result, Italian law today recognizes only the biological parent, and joint adoption by gay couples isn’t allowed.
Italian courts have been left to fill that gap in a haphazard way, with some judges approving adoption requests by gay partners of a biological parent and others turning them down. The result: up to 1,000 children of gay couples are caught in a legal limbo.
...
"Riccardo and Lorenzo, the Trento couple who released only their first names, sought to break new ground. The pair, an entrepreneur and a civil servant in their 50s who have been together for more than 20 years, were married in Canada. Their twins were born in Canada via surrogacy, a practice that is illegal in Italy. Canadian law allowed both men to be listed as the twins’ fathers on the birth certificate.
Once back in Italy, the couple sought to have the Italian state recognize the Canadian birth certificate, seeking a parental status that affords more rights than adoption in Italy. An adoptive parent’s relatives have no legal relation with the adopted children, who therefore have no legal status when it comes, for instance, to inheritance from grandparents. The court granted the couple’s request, effectively recognizing both men as fathers.
“[We] sought no more than to see our children’s legal family rights protected, just as with other families,” they said in a statement.
Nichi Vendola, a gay Italian politician and leader in the fight for same-sex rights, hailed the decision. “When you raise, care for and love a child, you’re a father, mother, parent,” he said.
In Italy, however, court decisions don’t set legal precedent, so the legislative gap remains for parliament to fill. With Italy headed to elections this year or next, there is little political appetite to take up the bruising battle over parenting rights again."
From New Zealand, a story with several notable features:
the patient received a heart-lung transplant, and her heart was successfully donated to another patient, at a time when deceased donation (and brain death) gave rise to some repugnance: Kay Burnett celebrates 30 years of a ground-breaking heart-lung transplant
"Sir Magdi Yacoub calls Burnett an outlier. One of the few who broke the statistics. The 81-year-old transplant surgery veteran speaks from Egypt, where he still teaches. These days, Sir Magdi is a globally revered transplant pioneer. He has a professorship, a knighthood and a membership of the Queen's exclusive Order of Merit. But back then, as Burnett sat in a London flat awaiting her only hope at life, some were calling him a murderer.
"It's easy to forget that transplanting organs from braindead patients was once deeply polarising. "The hate was abundant," Sir Magdi says. He won't repeat the hate mail's contents, but there was a lot of it – "a lot, a lot, a lot". ...
They said he was killing a living person to take their heart. "But the patient is not living. If my brain is dead – I'm not there."
...
"The domino-donor idea was born of Sir Magdi's frustration at wasting useable hearts. At the time, lung transplants were technically risky – even today they have lower survival rates. But transplanting a heart and lung together ensured the pressure generated by the heart was matched exactly by the lung. It also ensured an instant blood supply, helping the windpipe heal immediately.
"But for those, like Burnett, who needed only a new lung, that meant binning a potentially functioning heart.
"We were very short of donor organs. We still are. So I did not want to be sending it to the pathology department when I could be transplanting it."
"And so domino-donor transplants were born. While the domino-donor hearts were compromised, having been subjected to high blood pressure from the lung, or pulmonary hypertension, Sir Magdi realised that could be an advantage. Heart patients with severe pulmonary hypertension could receive a heart pre-conditioned to that high pressure, which then normalises over time.
"Burnett's was not the first domino-donor transplant – that was undertaken by Sir Magdi 11 days earlier, on April 28. The heart-lung recipient survived; the heart recipient did not.
History now mostly says the first successful domino transplant was conducted in the United States, but contemporary news reports say Burnett's transplant happened just hours earlier. Burnett was all over the British press, with The Sun once reporting her dead.
Who was first is not important, Sir Magdi insists. What matters is learning from people such as Burnett and Andrew Whitby – another Harefield patient, named the longest-surviving heart-lung transplant recipient when his 30-year anniversary ticked over in 2015.
Here's a forthcoming article in Transplantation, interesting for both what it says and who says it.
The authors include prominent transplant professionals at UCLA (which is an important, innovative and productive kidney transplant center), and also the rising-star economist and matching theorist Marek Pycia. I recall a time when collaborations between economists and transplant professionals was unusual, and so I'm glad to see new collaborations of that sort arise.
The paper itself is about taking future care of young kidney patients who may need a (second or third) kidney donation later in life. The NKR and UCLA are implementing a voucher system that would allow a donor (e.g. the young patient's grandparent, or parent) to donate as a non-directed donor today, on behalf of a specific, current kidney patient, in return for a commitment that best efforts would be made to end some future kidney exchange chain with a chain-ending kidney for the designated patient, when the need arises.
TransplantationPublished Ahead of Print DOI: 10.1097/TP.0000000000001744 Abstract Background: The waiting list for kidney transplantation is long and growing. The creation of :vouchers" for future kidney transplants enables living donation to occur when optimal for the donor and transplantation to occur later, when and if needed by the recipient. Methods: The donation of a kidney at a time that is optimal for the donor generates a :voucher‘" that only a specified recipient may redeem later when needed. The voucher provides the recipient with priority in being matched with a living donor from the end of a future transplantation chain. Besides its use in persons of advancing age with a limited window for donation, vouchers remove a disincentive to kidney donation, namely, a reluctance to donate now lest one‘s family member should need a transplant in the future. Results: We describe the first 3 voucher cases, in which advancing age might otherwise have deprived the donors the opportunity to provide a kidney to a family member. These 3 voucher donations functioned in a nondirected fashion and triggered 25 transplants through kidney paired donation across the United States ********** See my earlier post:
Here's the web page and program in Italian and in English (click on the Union Jack)
Here's a page describing the three events that I'll take part in on June 1 and 2. In the first I'll speak about market design and kidney exchange, in the second about my book, which recently came out in Italian, and the third event will be a panel discussion of repugnant transactions:
To what extent can facilitating the bringing together of supply and demand for organs save human lives and reduce health inequality? In particular, is it possible to organise the exchange of kidneys efficiently, taking into account ethical and regulatory restrictions? To what extent is this exchange between rich and poor countries manageable on a global scale?
In Italy, as in many other countries, the demand for transplant organs exceeds supply, and the gap is increasing over time. Is it possible to consider the idea that providing monetary payment for donors or other forms of exchange, as takes place in other countries, may contribute towards filling the gap between supply and demand? Is there not a risk of introducing unacceptable forms of exploitation and unfairness?
Featuring Ike Brannon, Visiting Fellow, Cato Institute; Jeremy Marcus, Legislative Director and Deputy Chief of Staff, Rep. Matt Cartwright; Sally Satel, M.D., Senior Fellow, American Enterprise Institute; Keith Melancon, M.D., Director, George Washington Transplant Institute; Kurt Schuler, Kidney Donor; moderated by Peter Russo, Director of Congressional Affairs, Cato Institute.
The video is 38 minutes of interesting, moderate discussion, and ends rather abruptly--I gather the discussion continued beyond the video.
Historian of Economics Beatrice Cherrier blogs about the two Golden Goose Awards that have been made for various parts of market design (in 2013 and 14), and suggests that more deserving topics could have been picked...
In a business where individual patients may pay vastly different fees depending on whether they are being supported by Medicare or by private insurance, there is room for game playing.
Government funding of science is important, and at risk. Here's an opinion piece that ran yesterday in Alabama, which seeks to bring some of the direct benefits in Alabama to the attention of Alabama's citizens and representatives in Washington (using the active kidney exchange program in Alabama as an example).
Trump budget puts future scientific advances at risk
By Alvin E. Roth, the Craig and Susan McCaw Professor of Economics at Stanford University
and Dr. Jayme Locke, Associate Professor at UAB School of Medicine and the Director of the Incompatible Kidney Transplant Program and Transplant Analytics, Informatics & Quality
Here are the final paragraphs:
"As the Director of the Incompatible Kidney Transplant Program at UAB and a Nobel Prize winning economic researcher, we have seen first-hand the power of science to connect those suffering with disease with vital cures.
We applaud Senator Shelby as a leader of the Senate Appropriations Committee, and Representatives Aderholt and Roby on the House Appropriations Committee, as well as all of the Alabama Congressional delegation on their work to support vital R&D investments in a bipartisan way.
We are hopeful that leaders will once again demonstrate that funding America's future innovation is a bipartisan imperative. "