Kidney exchange: the donor stories, and the movie Abundant

 I'm learning a bit about movie production by following the progress of the movie Abundant, which is about to have a pre-release premier.  Here is the trailer (sponsored by the APKD), and the press release.

Here's the trailer:  https://vimeo.com/1048377579

 

And here's the press release:

LOS ANGELES--(BUSINESS WIRE)--ABUNDANT, a documentary film that follows the unbelievable events surrounding extreme altruists who donated kidneys to complete strangers, has set its world premiere in Hollywood at The Directors Guild of America Theater Complex on March 1, 2025. The event is presented by OneLegacy Inspires Hollywood and The National Kidney Donation Organization (NKDO) as a kickoff to National Kidney Month. OneLegacy Inspires Hollywood champions authentic and accurate storytelling that highlight the power of organ, eye and tissue donation and transplantation.

“ABUNDANT moves us beyond a mindset of scarcity, reminding us of our shared humanity and connection”

The film’s world premiere is an entertainment industry event to showcase the often-miraculous stories connected to altruistic acts such as living kidney donation. “ABUNDANT moves us beyond a mindset of scarcity, reminding us of our shared humanity and connection,” said Sarah E. Fahey, Chair of OneLegacy Inspires Hollywood. “Through a powerful emotional journey of joy, grief, and hope, the film keeps audiences engaged from start to finish—and lingers long after the credits roll. OneLegacy Inspires Hollywood is thrilled to partner with NKDO and Maitri River Productions to premiere this impactful story during National Kidney Month here in Hollywood. This is the movie Los Angeles, and the world, needs right now,” Fahey added.

The choice of Los Angeles for ABUNDANT’s world premiere was in part inspired by the widespread acts of generosity, kindness and abundance displayed by the Los Angeles community during the recent wildfires. “One thing became obvious to me about abundance and altruism when I was making ABUNDANT,” said Director Donald Griswold. “Acts of abundance or generosity don’t have to be life-saving or dramatic to impact another person’s life meaningfully. We’re all fascinated by the non-directed kidney donors who give a kidney to a stranger, but viewers walk away from the film realizing that small acts and everyday kindnesses make an important impact, too. We saw that in so many ways in LA these last few weeks. We had to show ABUNDANT for the first time here and now.”

National Kidney Donation Organization supports ABUNDANT as part of an effort to gain more attention for kidney donation stories. “We are proud to have a hand in sharing this life-affirming message of hope and goodness with the people of LA, and with all those across the country who might be inspired by it,” said Emily Polet-Monteserro, Executive Director, National Kidney Donation Organization. “This compelling film uses the vehicle of kidney donation to encourage the audience to consider what it means for them to live fully and with love toward everyone, including strangers.”

ABUNDANT includes interviews with 2012 Nobel Prize Laureate Alvin Roth, PhD, Freakonomics Radio host Stephen Dubner, author and researcher Abigail Marsh, PhD, and business leader in the field of system change, Tynesia Boyea-Robinson among other notable personalities. The film features first-hand stories of non-directed kidney donation (where a person donates a kidney to a complete stranger) in a never-before-seen way of telling stories. 

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Earlier:

Tuesday, September 24, 2024

Abundant: a moving documentary about living organ donors

Exceptional altruism: living organ donors who donate twice

 Some living donors are moved to do it twice: first a kidney, and then later a liver, or the other way around. It appears that this is trending upwards in the last few years.

 

Second Time Around: Increased Rate of Living Donation From Repeat Organ Donors  by Carolyn N Sidoti 1, Kelly Terlizzi 1, Conor Donnelly 1, Ian S Jaffe 2, Jennifer D Motter 1, Benjamin Philosophe 3, Reed T Jenkins 3, Sarah Hussain 3, Pedro Colon 2, Amit D Tevar 4, Bonnie E Lonze 1, Babak J Orandi 1 5, Macey L Levan 1, Dorry L Segev 1 6, Allan B Massie, Clin Transplant,  2025 Jan; 39(1):
 https://onlinelibrary.wiley.com/doi/10.1111/ctr.70049

"Abstract
Introduction: Some living organ donors will decide to donate again at a later date. Evidence has indicated that this practice may have increased in recent years. We evaluated the incidence and outcomes of this practice to inform counseling of potential repeat donors.

Methods: Using SRTR data from 1994 to 2023, we identified 220 repeat living donors and their 415 recipients. We constructed donor comparison groups using weighting by the odds. We described clinical and lab results at 6 months, 1 year, and 2 years post-donation separately for kidney-second donors and liver-second donors. We compared all-cause graft failure for their recipients with those of comparison donors.

Results: The annual count of repeat living donors increased from 5 in 2018 to 25 in 2019 (p < 0.001). Of 220 donors, 159 were liver-second donors (72.3%) and 55 were kidney-second donors (25.0). The percentage of nondirected donations increased from 30.5% at first donation to 53.2% at second donation (p < 0.001). Liver-second donors had one death approximately 2.5 years post-donation. Seventeen were re-admitted and 20 experienced complications requiring an interventional procedure or re-operation. Among kidney-second donors, no deaths, re-admissions, or post-donation complications were reported. Post-donation outcomes in both groups were comparable when evaluated against organ-specific comparison donors. Recipients of repeat living donors experienced graft survival similar to recipients of comparison donors.

Conclusions: Repeat living donation may be a safe practice for carefully selected living donors in the short term; however, long term safety is unknown. Outcomes for recipients are similar to recipients of comparison donors."

...

"The first reported instance of repeat living donation occurred in 1981 when a living kidney donor went on to donate a segment of their pancreas 2.3 years later [1].  

Kidney exchange chain at Ohio State--a gift transforms 20 lives

 Here's a recent big kidney exchange chain, begun by a nondirected donor, involving patient-donor pairs all at OSU's medical center

The Columbus Dispatch has the story. (If I had written the headline, it would have said "transforming 20 lives," since many of the donors I've met have also been transformed.)

Ohio State Wexner sets record-breaking kidney 'donation chain,' transforming 10 lives   by Samantha Hendrickson

"On Dec. 13, Samantha Fledderjohann donated one of her kidneys to a stranger in need, and in the process, transformed 10 lives.

The 46-year-old was the first of a record-breaking "chain" of 20 surgeries over a two-day period at the Ohio State University Wexner Medical Center Comprehensive Transplant Center, both to remove and transplant kidneys from 10 living donors to 10 recipients. That means 10 people now have another chance to live more of their lives better and longer with a healthy kidney.

...

"The transplant swap begins with an "altruistic non-directed" donor like Fledderjohann, who saw a need for more kidney donors, and felt an internal pull to donate even without someone in mind

...

"The "chain reaction" continued, thanks to individuals like Carnahan staying on OSU's donor list despite not being a match for a loved one, instead extending that offer to a stranger in need.

...

"According to the Organ Procurement and Transplantation Network, there are 104,840 people on the transplant waitlist and 90,506 need a kidney in the United States, and 2,079 of them live in Ohio. Ohio State’s transplant center has performed more than 8,500 kidney transplants since 1967."