Explaining plasma donation

In recent posts I've commented on the repugnance (in Canada and elsewhere) to paid plasma donation, which is legal in the U.S.. (The U.S. consequently supplies much of the world's plasma needs.)  One question facing the plasma industry is how to defend against compensated plasma donation being seen as a repugnant transaction.

I think they are already very well equipped to communicate the need for plasma proteins, which provide treatments for a host of diseases, and which are used around the world.  But to the extent that (paid or unpaid) donation needs to be defended and encouraged, I would expect to see more stories like this one, from Australia.

This man's blood has saved 2.4 million babies
'I'd keep going if they let me,' says 81-year-old with magical plasma.

"The man with the golden arm

"Harrison's blood is valuable because he naturally produces Rh-negative blood, which contains Rh-positive antibodies. His blood has been used to create anti-D in Australia since 1967.

"Every ampule of Anti-D ever made in Australia has James in it," Robyn Barlow, the Rh program coordinator who recruited Harrison, told the Sydney Morning Herald. "Since the very first mother received her dose at Royal Prince Alfred Hospital in 1967."

Harrison was the program's first donor.

"It's an enormous thing ... He has saved millions of babies. I cry just thinking about it."

Since then, Harrison has donated between 500 and 800 milliliters of blood almost every week. He's made 1,162 donations from his right arm and 10 from his left.

...

Harrison's retirement is a blow to the Rh treatment program in Australia. Only 160 donors support the program, and finding new donors has proven to be difficult. Additionally, attempts to create a synthetic version of anti-D have failed."

Chen Yusun Memorial Lecture at Tsinghua. 陈岱孙纪念讲座

Monday, at Tsinghua University I'll have the honor of delivering the
Chen Daisun Memorial Lecture, 陈岱孙纪念讲座

From Google translate:
"In order to celebrate the centennial birthday of Tsinghua University and the 85th anniversary of the Department of Economics of Tsinghua University, the Tsinghua School of Economics and Management launched the "Chen Yisun Economics Memorial Lecture" in April 2011.

Professor Chen Yusun was born in 1900. He graduated from Tsinghua University in Beijing in 1920. After earning an undergraduate degree in economics from the University of Wisconsin in 1922, he went to Harvard University for further studies and received his Ph.D. in economics in 1926. Among his classmates studying at Harvard University's Department of Economics, Bertil Ohlin, one of the Hecksell-Ohlin international trade models, and Edward Chamberlain, known for his theory of oligopolistic competition. (Edward Chamberlin). In 1928, Professor Chen Yisun returned to China. In the same year, he served as professor and department head of the Department of Economics at Tsinghua University. Until 1952, the Department of Economics of China's higher education institutions was merged into other universities. Professor Chen Yisun died in 1997 at the age of 97. Professor Chen Yusun is recognized as the father of modern economics education in China. Under his leadership, the Department of Economics of Tsinghua University became one of the best economics departments in China at that time. During his tenure, Professor Chen Yisun was the most undergraduate student at Tsinghua University, accounting for about one-fifth of all undergraduate students in the university.

The lecture was titled Professor Chen Yusun and is the highest level academic lecture for teachers and students. Previous speakers include: 1997 Nobel Laureate in Economics, Myron Scholes, Professor of Finance, Stanford Business School, 2007 Nobel Laureate in Economics, Professor of Harvard University, USA Eric Maskin, winner of the 1997 Nobel Prize in Economics, Robert C. Merton, a professor at the Massachusetts Institute of Technology, and winner of the 2013 Nobel Prize in Economics, University of Chicago professor Lars Peter Hansen."

I'll speak on "Repugnant transactions and forbidden markets"

Tsinghua Conference on Behavioral, Experimental and Theoretical Economics (BEAT), July 9-10

Tsinghua Conference on Behavioral, Experimental and Theoretical Economics

(Tsinghua BEAT 2018)

July 9-10, 2018

Keynote speakers:

Jacob Goeree, University of New South Wales

Ed Hopkins, University of Edinburgh

Alvin Roth, Stanford University (2012 Nobel Laureate in Economics)

We are pleased to announce the 2018 Tsinghua Conference on Behavioral, Experimental and Theoretical Economics (shortened as Tsinghua BEAT). The conference will be held on the campus of Tsinghua University, at the School of Economics and Management, in Beijing on July 9-10, 2018. 

Program Overview:

Detailed paper schedule: Tsinghua BEAT 2018 (PDF)

Conference website: http://tinyurl.com/tsinghuabeat

Monday July 9th

Session Chair:  Tracy Xiao Liu

09:00 – 10:00    The Favored but Flawed Simultaneous Multiple Round Auction, Jacob Goeree*(joint with Nick Bedard, Philippos Louis, and Jingjing Zhang)

Information and Communication

10:15 – 10:45   Costly Miscalibration in Communication, Yingni Guo* (Northwestern) and Eran Shmaya

10:45 – 11:15   Robust Persuasion of a Privately Informed Receiver, Ju Hu and Xi Weng*

11:15 – 11:45   Ambiguous Persuasion, Dorian Beauchêne, Jian Li* (McGill) and Ming Li

Market Design

13:00 – 13:30   Core of Convex Matching Games, Xingye Wu* (Columbia/Tsinghua)

13:30 – 14:00   A Dynamic College Admission Mechanism in Inner Mongolia: Theory and Experiment, Binglin Gong and Yingzhi Liang* (Michigan)

14:00 – 14:30 Obvious Mistakes in a Strategically Simple College Admissions 

Environment: Causes and Consequences, Ran I. Shorrer and Sándor Sóvágó* (Groningen)

Search and Information Preference

14:45 – 15:15  Sequential Search with a Freeze Option - Theory and Experimental Evidence, Emanuel Marcu and Charles N. Noussair* (Arizona)

15:15 – 15:45  Information Avoidance and Medical Screening: A Field Experiment in China, Yufeng Li, Juanjuan Meng, Changcheng Song* (NUS) and Kai Zheng

Chen Daisun Lecture, Main Auditorium, Weilun Buiding, chaired by Yingyi Qian, Dean of School of Economics and Management, Tsinghua University

16:15 – 17:30  Repugnant Transactions and Forbidden Markets, Alvin Roth, Stanford University, 2012 Nobel Laureate in Economics

Tuesday July 10th

Session Chair:  Alexander White

09:00 – 10:00   Price Dispersion and Cycles: Theory and Experiment, Ed Hopkins* (joint with Tim Cason and Dan Friedman)

Development

10:15 – 10:45   Targeting High Ability Entrepreneurs Using Community Information: Mechanism Design In The Field, N. Rigol, R. Hussam and Benjamin Roth* (Harvard)

10:45 – 11:15   Prosocial Compliance in P2P Lending: A Natural Field Experiment, Ninghua Du, Lingfang Li* (Fudan), Tian Lu and Xianghua Lu

11:15 – 11:45   Does Haze Cloud Decision Making? A Natural Laboratory Experiment, Soo Hong Chew, Wei Huang and Xun Li* (Wuhan)

Reputation and Risk

13:00 – 13:30   Reputation Effects under Interdependent Values, Harry Di Pei* (MIT/Northwestern)

13:30 – 14:00   The Persistent Power of Promises, Florian Ederer* (Yale) and Frédéric Schneiderz

14:00 – 14:30   Intertemporal Consumption with Risk: A Revealed Preference Analysis, Joshua Lanier, Bin Miao* (SUFE)， John Quah and Songfa Zhong

Cognitive Biases

14:45 – 15:15   Motivated Framing Effects, Christine L. Exley and Judd B. Kessler* (Penn)

15:15 – 15:45   Are People Aware of Their Inattention: Evidence from Credit Card Repayment, Jiajun Jiang, Yi-Tsung Lee, Yu-Jane Liu and Juanjuan Meng* (Peking)

15:45 – 16:15   Competing by Default: A New Way to Break the Glass Ceiling, Nisvan Erkal, Lata Gangadharan and Erte Xiao* (Monash)

Organizing Committee:

Chong-En Bai

Yan Chen

Ming Gao

Audrey Hu

Tracy Xiao Liu

Alex White

Jie Zheng

Xiaohan Zhong  

Market design comes to Harvard Law School

Here's a piece from the Harvard Law Bulletin that caught my eye:
Holger Spamann brings new thinking to the structure of his class and casebook 

He's teaching "a corporate finance course divided into four different modules, any of which students can opt out of depending on their knowledge level.

"A student who comes in with a great deal of experience in the field will be able to skip the initial module on basic valuation. Subsequent modules cover diversification and market efficiency, capital structure, and then finally auctions and market design. Students who want to only dip their feet can opt out of later modules.

"Spamann, who also earned a master’s and Ph.D. in economics from Harvard and practiced briefly as an M&A attorney, says his background in economics informs his approach to corporate finance and how he teaches the subject."
********

Spamann and Guhan Subramanian also have a casebook for sale: here's the Amazon link.

Corporations: Casebook Paperback – September 2, 2017

by Holger Spamann (Author), Guhan Subramanian (Author)

Is altruism necessarily good?

That's basically the question asked, in the context of organ donation, by this paper in the BMJ:

Law, ethics and medicine
Paper
How altruistic organ donation may be (intrinsically) bad
Dr Ben Saunders, Social Sciences, University of Southampton, Southampton SO17 1BJ, UK; b.m.saunders@soton.ac.uk

Abstract: It has traditionally been assumed that organ donation must be altruistic, though the necessity of altruistic motivations has recently been questioned. Few, however, have questioned whether altruism is always a good motive. This paper considers the possibility that excessive altruism, or self-abnegation, may be intrinsically bad. How this may be so is illustrated with reference to Tom Hurka’s account of the value of attitudes, which suggests that disproportionate love of one’s own good—either excessive or deficient—is intrinsically bad. Whether or not we accept the details of this account, recognising that altruistic motivations may be intrinsically bad has important implications for organ procurement. One possible response is to say that we should take further measures to ensure that donors have good motives—that they are altruistic is no longer enough. An alternative is to say that, since altruistic donation need not be intrinsically good, we have less reason to object to other motivations. 

In a nutshell:

"we may think that the virtue of altruism lies between selfishness (excessive self-concern) and self-abnegation (deficient self-concern). While it is probably true that most people ought to be less selfish, if someone shows little or no concern for her own well-being, this too could be morally troublesome. This might explain worries about the motives of some altruistic donors; we may fear that they are ‘too altruistic’ or not sufficiently concerned with their own good."

Compensation for kidney donors debated in WSJ

Familiar positions, clearly stated, pro and con compensation for donors.
There are other reasons put forward for not rewarding organ donation, but the one espoused here (preserving "the ability for one to aspire to virtue") is perhaps the one I have the least sympathy with, as it seems to value the hope of heaven more than saving earthly lives...

How to Provide Better Incentives to Organ Donors
Three experts discuss strategies to address the shortage of organs available for people who need transplants

"We talked about options for increasing organ donation with Sally Satel, a doctor and fellow at the American Enterprise Institute and the beneficiary of two kidney donations; Alexandra Glazier, chief executive of New England Donor Services, which coordinates organ and tissue donation in six New England states and Bermuda; and Andrew Flescher, a professor of public health and English at the State University of New York at Stony Brook, and author of “The Organ Shortage Crisis in America.”
...
"WSJ: The gap between the number of people who need organs and the number of organs available continues to grow. Why is our current model failing to bridge that gap?

DR. SATEL: Having studied the issue for 12 years, since my first kidney transplant, I am convinced that the only solution—before technology makes donation from people obsolete, and it will—is to compensate potential organ donors.

PROF. FLESCHER: The way forward is living donation. Roughly 100,000 out of 120,000 folks who need an organ need a kidney, which can be procured from a living donor, as most of us are born with two kidneys. We need a way of getting everyone to care about the plight of folks on dialysis, not through any coercive measure, of course, but through simple exposure.

MS. GLAZIER: There is no question that need outpaces the supply significantly. That said, it’s important to recognize that the number of deceased organ donors in the U.S. has increased 26% in the past five years (2012-2017) and the number of organs transplanted has increased 28% over the same period. In the New England region, the increase was more than double this rate over the same time period.

...

"PROF. FLESCHER: I certainly do not think paying living donors is the way to go.

DR. SATEL: But what is left? I suppose the real question is what is so aversive about enrichment of some kind? Surely, we do it with plasma, egg, sperm, body, as in donations in medical schools, maternal surrogacy, breast milk, hair. We already pay for body products. And, of course, my colleagues and I do not recommend lump-sum cash, because we do not want to attract desperate, impulsive people who may regret acting. Instead, rewards could include things like tax credits, lifetime health insurance, a contribution to a 401(k) account or a tuition voucher.

PROF. FLESCHER: The introduction of money for a precious good comes at the cost of the ability for one to aspire to virtue, if not as hero, than as a civic-minded, socially conscious neighbor, free to act, and to be perceived as acting, out of the motive to offer help to one in need.

...

"WSJ: Sally, can you please sum up the central tenets of how compensation for living donors would work?

DR. SATEL: The principles of a system of compensation are these: 1. Informed consent. 2. Ensuring health protection, before and after. 3. An ample reward—something trivial amounts to exploitation. 4. Respect for autonomy of people who know what is in their best interest. 5. Expression of gratitude for the lifesaving act they performed.

I suggest a waiting period of six to 12 months to ensure that the would-be donor is sure he or she wants to proceed. And a noncash reward, because a cash reward will appeal to impulsive decision makers, and we need to avoid that.

Obstacles to kidney exchange in Germany

An op-ed in yesterday's Handelsblatt Global (in English) proposes that kidney exchange should be allowed in Germany:
Germany should allow donating organs to strangers
by Fabian Kurz and Fred Roeder, July 2, 2018

An earlier brief discussion/blog post (in German) with some interesting links describes some of the current obstacles to kidney exchange in Germany:

Nieren-Tausch kann Leben retten (Kidney exchange can save lives)
von Alexander Fink & Fabian Kurz, 20. Juni 2018

Here's the German Transplant Act.

Here's a ruling of the German Federal Social Court, confirming the effective ban on kidney exchange.

Here's a 2005 news story about two patient-donor pairs who were allowed to engage in a kidney exchange after arguing that they had established a sufficient relationship with each other, to fit the requirement of the law that transplants can only be received from close relations, i.e. immediate family, or a "special personal bond" .
Nieren-Tausch soll Leben retten (Kidney exchange is supposed to save lives)
***********

Some earlier discussions and links:

Thursday, March 17, 2016

Transplants in Germany, further discussion of changing the transplant law, in Der Tagesspiegel

Sunday, January 21, 2018

The number of organ donors in Germany has fallen to its lowest level in 20 years.

Wednesday, February 21, 2018

Organ donation in Germany

Organ donation in Germany is declining, from an already low rate.

Kidney exchange in all its aspects: a view from India

Here's a survey that sees kidney exchange, and all the advances that have been made in how to use it to facilitate more transplants, as a force for making medicine more inclusive around the world.

Kidney exchange transplantation current status, an update and future perspectives
Vivek B Kute, Narayan Prasad, Pankaj R Shah, Pranjal R Modi
World J Transplant. Jun 28, 2018; 8(3): 52-60
Published online Jun 28, 2018. doi: 10.5500/wjt.v8.i3.52

Abstract: "Kidney exchange transplantation is well established modality to increase living donor kidney transplantation. Reasons for joining kidney exchange programs are ABO blood group incompatibility, immunological incompatibility (positive cross match or donor specific antibody), human leukocyte antigen (HLA) incompatibility (poor HLA matching), chronological incompatibility and financial incompatibility. Kidney exchange transplantation has evolved from the traditional simultaneous anonymous 2-way kidney exchange to more complex ways such as 3-way exchange, 4-way exchange, n-way exchange,compatible pair, non-simultaneous kidney exchange,non-simultaneous extended altruistic donor, never ending altruistic donor, kidney exchange combined with desensitization, kidney exchange combined with ABO incompatible kidney transplantation, acceptable mismatch transplant, use of A2 donor to O patients, living donor-deceased donor list exchange, domino chain, non-anonymous kidney exchange, single center, multicenter, regional, National, International and Global kidney exchange. Here we discuss recent advances in kidney exchanges such as International kidney exchange transplantation in a global environment, three categories of advanced donation program, deceased donors as a source of chain initiating kidneys, donor renege myth or reality, pros and cons of anonymity in developed world and (non-) anonymity in developing world, pros and cons of donor travel vs kidney transport, algorithm for management of incompatible donor-recipient pairs and pros and cons of Global kidney exchange. The participating transplant teams and donor-recipient pairs should make the decision by consensus about kidney donor travel vs kidney transport and anonymity vs non-anonymity in allocation as per local resources and logistics. Future of organ transplantation in resource-limited setting will be liver vs kidney exchange, a legitimate hope or utopia?"

An interesting section of the paper discusses different practices regarding anonymity in kidney exchange centers in different countries:

"PROS AND CONS OF ANONYMITY IN DEVELOPED WORLD AND (NON-) ANONYMITY IN DEVELOPING WORLD

There is disparity on standard practice of kidney exchange in developed and developing World in term of (non-) anonymity. There is variable practice on anonymity before and after surgery in different countries.

Conditional approach[38]: When the donor-recipient pairs give consent for meeting after surgery, they are allowed to meet each other after surgery in some countries such as the United States of America[39] and the United Kingdom[40]. In other countries, such as the Netherlands and Sweden[41], anonymity is absolute. Anonymity protects patients, donors and transplant hospital/ administration against the risks of revoking anonymity and prevents further commercialization of organs, and breach of patient donor privacy. An Ethical, Legal and Psychosocial Aspects of Organ Transplantation (ELPAT), a subsection of the European Society for Organ Transplantation reported that a conditional approach to anonymity should be possible after surgery[42]. Pronk et al[38] showed that most donor-recipient pairs who participated in anonymous donation process are in favour of a conditional approach to anonymity. Guidelines on how to revoke anonymity if both parties agree are needed and should include education about pros and cons of (non-) anonymity and a logistical plan on how, when, where, and by whom anonymity should be revoked.

Non-anonymous allocation[11,12]: Donor-recipient pairs are allowed to meet each other before allocation of donor for surgery and even after surgery. They can share medical reports of exchange donors before surgery and kidney transplant and donor surgery outcome after surgery. Donor-recipient pairs do not choose their match but donor-recipient pairs may decline a match or can withdraw from participation in the kidney exchange program at any time, for any reason. Non-anonymous allocation has the potential of commercialization of organs in case of compatible donor-recipient pairs along with breach in privacy of donor-recipient pairs. Kute et al[11,12] reported that donor-recipient pairs are willing for non-anonymous allocation process in single center study of 300 kidney exchange transplants in India. They reported that non-anonymity is more helpful in manual allocation in absence of computer software allocation which also increases trust between patients, donors and transplant hospital/administration and legal team. More long term prospective studies are required to explore the donor and recipient perspective on anonymity in living kidney donation in different socio-economic regions and countries."

Regarding Global Kidney Exchange they conclude:

"Global kidney exchange appears to provide life-saving kidney transplantation to poor donor-recipient pairs from developing countries that otherwise could die due to economic constrain[50-53]."

And here's their conclusion:

CONCLUSION

"Kidney exchange transplantation has increased living donor kidney transplantation for end stage renal disease patients with chronological incompatibility and financial incompatibility. The participating transplant teams and donor-recipient pairs should make the decision by consensus about kidney donor travel vs kidney transport and anonymity vs non-anonymity in allocation as per local resources and logistics. There is need of uniform algorithm for management of incompatible donor-recipient pairs."

Ariel Pakes gives the Arrow Lecture in Jerusalem

If you're in Jerusalem tomorrow, you have a chance to hear Ariel Pakes' Arrow Lecture:

17:00-18:00 Ariel Pakes, Arrow lecture:

Learning and Equilibrium in A New Market

It is part of

The 29th Jerusalem Summer School of Economics

Industrial Organization

Event date: June 26 - July 5, 2018 

Organizers:

Eric Maskin, General Director (Harvard University)
Ariel Pakes, Codirector (Harvard University)
Elchanan Ben-Porath,Codirector (The Hebrew University)





Industrial Organization studies how markets are structured and the way they respond to changes in conditions (e.g., to policy revisions). The field draws heavily on both theory and empirical work, and both will be amply represented in the Summer School. We will focus on several topics of current research interest: vertical markets, allocation in markets without prices, market dynamics, and regulation.


  
List of speakers:


NAME AFFILIATION EMAIL TOPICS Nikhil Agarwal Massachusetts Institute of Technology agarwaln@mit.edu The analysis of centralized market allocation mechanisms John Asker The University of California johnaskecr@econ.ucla.edu The analysis of regulation Alon Eizenberg  The Hebrew University of Jerusalem       aloneiz@mscc.huji.ac.il The analysis of regulation Myrto Kalouptsidi Harvard University  myrto@fas.harvard.edu The analysis of market dynamics Robin Lee Harvard University robinlee@fas.harvard.edu The   analysis of   vertical markets Eric Maskin          Harvard University emaskin@fas.harvard.edu  The analysis of market dynamics Ariel Pakes Harvard University apakes@fas.harvard.edu The analysis of market dynamics Parag Pathak Massachusetts Institute of Technology ppathak@mit.edu The analysis of centralized market allocation mechanisms Mike Whinston Massachusetts Institute of Technology whinston@mit.edu The analysis of vertical markets Ali Yurukoglu Stanford University ayurukog@stanford.edu The analysis of regulation

Here's a link to the full program.

There will be several sessions on matching markets:

Wednesday, July 4

9:30-11:00 Parag Pathak: Introduction to Matching Theory

11:00-11:30 Coffee Break

11:30-13:00 Nikhil Agarwal: Revealed Preference for Matching Markets

Thursday, July 5

9:30-11:00 Parag Pathak: Market Design Meets Research Design

11:00-11:30 Coffee break

11:30-13:00 Nikhil Agarwal: The Organization of Organ Markets