Friday, May 31, 2019

Xenotransplants, Baby Fae, and the complex pioneering efforts of Dr. Leonard Bailey, RIP

The recent death of Dr. Leonard Bailey (who performed the first successful heart transplant to an infant) reminded me of how so many ultimately successful stories in organ transplantation begin with rather wild shots in the dark, involving patients who have little to lose.

Here's the NY Times obituary:

Dr. Leonard Bailey, Who Gave a Baby a Baboon’s Heart, Dies at 76
By Denise Grady, May 22, 2019

"Dr. Leonard L. Bailey, who elicited both admiration and outrage by transplanting the heart of a baboon into a dying infant in 1984, died on May 12 at his home in Redlands, Calif. He was 76.
"Although Dr. Bailey went on to pioneer human heart transplants for infants, and to build a renowned center for children’s cardiac surgery at Loma Linda University in Southern California, he remained best known to the public as the doctor behind the wrenching story of the infant known as Baby Fae.

"“I knew she was going to die, and I had to try,” Ms. Beauclair [Baby Fae's mom] said in a telephone interview. “If I hadn’t tried, I always would have wondered, could we have saved her?
"The operation took place on Oct. 26, 1984. At first, Stephanie seemed to thrive. During a news conference at the hospital, Dr. Bailey was ebullient, describing her as a “beautiful, healthy baby” whose transplanted heart was doing “everything it should.”

"Baby Fae made headlines around the world. The public was enchanted by her. But reactions to the surgery ranged from awe to horror.
"Animal rights groups said killing the baboon was immoral and held demonstrations outside the hospital and Dr. Bailey’s home. He and the hospital received threats.

“This wasn’t a wild whim,” Dr. Roger Hadley, dean of Loma Linda University School of Medicine, said in an interview. “He had worked for years on doing cross-species transplants in animals. We had a whole lab of animals who had somebody else’s heart.”

"Dr. Hadley added that the hospital at Loma Linda is faith-based — the hospital and the university are run by the Seventh-day Adventist Church — and said that all its ethicists and theologians had thought that the transplant was the right thing to do.

“We stood by him here,” he said.
"Stephanie’s initial rally after the surgery did not last. Rejection and organ failure set in, and she died on Nov. 15, 1984. She had survived for 21 days.

"Her case helped focus concern on the plight of babies born with fatal heart defects, and the desperate need for organs. The next year, Dr. Bailey performed the first successful heart transplant in an infant, from a human donor. He went on to perform 375 more over the course of his career, as well as other types of pediatric heart surgery. He continued operating until 2017.

"Because of growing ethical concerns about experimenting on primates, research on using them as a source of organ transplants has mostly been abandoned. But efforts are underway to genetically alter pigs to make their organs compatible with humans."

Thursday, May 30, 2019

Alumni medals at Columbia

I am a proud grad of the Columbia University School of Engineering, which I attended as an undergraduate from 1968-1971.  I'll be back on campus this evening to get a medal, as will Dr. Harry L. Tuller.

You can read about us in the Columbia Engineering Magazine: Alumni Medalists 

Wednesday, May 29, 2019

Black markets in college graduation tickets

Here's a seasonal story, from the Guardian;

Need a college graduation ticket? There's a black market for that
Tickets for New York University’s 2019 commencement ceremony are being advertised for as much as $250

"It’s graduation season in the United States, which means lots of caps, gowns, pomp and circumstance, corny speeches, selfies – and an underground trade in graduation tickets to top off the celebrations.

"Many colleges and universities limit the number of people who can attend a graduation ceremony, providing students with tickets to the event they can distribute to friends and family. These tickets are often transferable, meaning someone can give a ticket to a friend who needs an extra seat. But this also means that students can sell their tickets – though banned by most schools – to get some extra cash.

"This “black market” around graduation has been documented for years, especially with the rise of social media networks. People from schools like Princeton, University of San Francisco and College of Charleston have advertised tickets for hundreds of dollars, the Wall Street Journal reported in 2007. At the University of Virginia, students sold tickets for an average price of $150 for last year’s commencement ceremony in Charlottesville.

"Now at New York University (NYU), tickets for the class of 2019’s commencement ceremony are being advertised for as much as $250."

Tuesday, May 28, 2019

Surrogacy and citizenship: bringing the babies home isn't always so easy

Even the U.S., which is a center of surrogacy, employs outdated rules to determine which surrogate children born overseas are automatically American citizens.  Here's a story from the NY Times which (among other things) involves reverse fertility tourism. The American male couple had a friend in Britain serve as the surrogate. (Mostly the tourism goes the other way, because British surrogates can't be paid, so they aren't easy to arrange....)

Both Parents Are American. The U.S. Says Their Baby Isn’t. By Sarah Mervosh.

"James Derek Mize is an American citizen, born and raised in the United States. His husband, who was born in Britain to an American mother, is a United States citizen, too.

"But the couple’s infant daughter isn’t, according to the State Department.

"She was born abroad to a surrogate, using a donor egg and sperm from her British-born father. Those distinct circumstances mean that, under a decades-old policy, she did not qualify for citizenship at birth, even though both her parents are American.
"The interpretation [of the law] has led the State Department to regard births from assisted reproductive technology as “out of wedlock,” if the source of the sperm and the egg do not match married parents. Such a designation comes with extra requirements for transmitting citizenship, including showing that a biological parent is an American citizen who has spent at least five years in the United States."

Monday, May 27, 2019

California surrogacy

Surrogacy serves all sorts of people, mostly couples who don't have a working womb between them. But, as Jenny Kleeman reports in the Guardian, it also can serve those whose need isn't medical. She interviews the controversial fertility doctor Vicken Sahakian, who is  known among other things for having helped a Spanish woman become the oldest known person to give birth, at 67.  Here's a link with some excerpts from the excellent, long article (read it all for more about the clients and the surrogates).

'Having a child doesn’t fit into these women's schedule': is this the future of surrogacy? 

"His clients are straight, gay, young and old, and they come to him from across the globe, particularly from China, or parts of Europe where surrogacy is either illegal or very tightly regulated. In the UK, surrogacy is legal, but surrogates can claim only expenses for carrying a child for another person. California law allows surrogates to earn a profit, and upholds the rights of intended parents over anyone else who is involved in the creation of their babies. It’s given the state a reputation as the most surrogacy-friendly place in the world.
"And as the range of fertility options open to clients has diversified, so have their requests. Now, a growing number of women are coming to Sahakian for “social” surrogacy: they want to have babies that are biologically their own, but don’t want to carry them. There is no medical reason for them to use a surrogate; they just choose not to be pregnant, so they conceive babies through IVF and then hire another woman to gestate and give birth to their baby. It is the ultimate in outsourced labour.
"Five years ago, Sahakian says he would preside over a handful of social surrogacy cases a year; now he sees at least 20. “More and more every year. ... It costs $150,000 to have a baby this way. “If social surrogacy was more affordable, more women would be doing it, absolutely. There’s an advantage to being pregnant, the bonding, I understand that, and from experience I can say that most women love to be pregnant. But a lot of women don’t want to be pregnant and lose a year of their careers.”
"The typical candidates are models and actors who are doing well but haven’t yet made their name. “They tell me point blank, ‘If I get pregnant, I will lose my part. I work, I don’t have time because of work. I model, I act, I look good like this and I don’t want to disfigure my body.’”
"The official guidelines set out by the American Society for Reproductive Medicine (ASRM) say that gestational carriers – surrogates who carry babies conceived through IVF, with eggs from another woman – should be used only when there is a medical need. But Sahakian has no qualms about “defining medical reasons broadly”, as he puts it. “What’s the end result here? Somebody wants to be a parent. I’m facilitating that. I understand that it’s controversial, it’s borderline unethical for some people, but put yourself in the shoes of a 26-year-old model who is making her living by modelling swimsuits. Tell me something – is it that unethical, to say let’s not destroy this woman’s career?”
"Sahakian has a reputation for pushing boundaries, and he relishes it: it’s given him a notoriety that drives his business. In 2001, he helped the oldest woman on record in France, Jeanine Salomone, conceive using donor eggs and give birth at 62. A scandal erupted in France – where both surrogacy and artificial insemination of post-menopausal women are illegal – when it emerged that Jeanine’s brother, Robert, was the biological father of the son she gave birth to. ...
The press descended on Sahakian, who said the siblings had presented themselves in his consulting room as a married couple [they had the same last names], and that Jeanine had lied about her age. "

Sunday, May 26, 2019

Same sex marriage comes to Taiwan

Here's the NY Times story on the new law allowing marriage, and on still to be debated issues including family formation (adoption, surrogacy...):

After a Long Fight, Taiwan’s Same-Sex Couples Celebrate New Marriages
By Chris Horton, May 24, 2019

"TAIPEI, Taiwan — Typically drab and nondescript, Taipei’s Xinyi District Household Registration office exploded with life and color on Friday morning.

"Taiwanese and foreign reporters surrounded the office’s main desk to witness history, as Taiwan became first in Asia to legally recognize same-sex marriages.
"The registrations came exactly a week after Taiwan’s legislature made headlines worldwide by voting to recognize same-sex marriage.
"Mr. Chi said that Taiwan’s separate-but-equal law for same-sex couples was a step in the right direction, but that more work remained to be done. Instead of having a separate law for gay couples, he said, Taiwan’s civil code should be amended to simply include all couples. The issues of transnational couples and full adoption rights also need the be addressed, he said.
"The law passed last Friday went beyond what the constitutional court demanded. The 2017 court ruling spoke in terms of the right to equality and freedom of marriage, but it did not address equality with respect to building a family, said Margaret Lewis, a law professor at Seton Hall.

Now the question is whether the court will be asked to rule on how the constitutional right to equality applies to adoption by married couples of the same sex,” she said. “Other issues of concern include whether to legalize surrogacy and changes to laws related to assisted reproductive technology.

Saturday, May 25, 2019

Matching comic from Saturday Morning Breakfast Cereal

I rely on comics to let me know important subjects to study (doesn't everyone?). Here's one from Saturday Morning Breakfast Cereal

Match-Up 2019 in Switzerland, May 26-29

Here's the program. (It contains abstracts following the schedule...)

Sunday, May 26th
14:00 - 14:15    Conference Opening (Bettina Klaus)
14:15 - 14:40“Stability Against Robust Deviations in the Roommate Problem”Daisuke Hirata, Yusuke Kasuya, andKentaro Tomoeda
14:40 - 15:05“Robust   Group   Strategy-Proofness”Steven   KivinenandNorovsambuu Tumennasan
15:05 - 15:30“Robust Design in Monotonic Matching Markets: A Case for Firm-Proposing Deferred-Acceptance”Lars Ehlersand Jordi Masso
15:30-16:00Coffee Break
16:00 - 17:20    Poster Presentation Session 1
“Preprocessing  in  Matching  Problems”  Maxence  Delorme,  Ser-gio  Garc`ıa,  Jacek  Gondzio,  Joerg  Kalcsics,  David  Manlove,  andWilliam Pettersson
“Legal  Assignments,  the  EADAM  (Efficiency  Adjusted  DeferredAcceptance   Mechanism)   Algorithm”   Yuri   Faenza   andXuanZhang
“A General Framework for Stable Roommate Problems: A Preliminary Report”Muge Fidan and Esra Erdem
“Preference Manipulation in Two-Sided Matching - Strategic Behavior and Robustness of Solution Algorithms” Christian Haas
“Practical Issues in Matching - A Case Study on Genetic Counseling Admissions in North America” Jonah Peranson
“Unpopularity Factor in the Marriage and Roommates Problems”Suthee Ruangwises and Toshiya Itoh
“School choice with priority levels:  Constrained Efficient and FairAssignment” Thomas Wouters

Monday,May 27

09:10 CSF Welcome Address
09:25 - 10:10    Invited  Talk“Parameterizing  Stable  Matching  Problems” Ildi Schlotter
10:10 - 10:35“Stable   Noncrossing   Matchings” Suthee   Ruangwises and Toshiya Itoh
10:35 - 11:05    Coffee Break
11:05 - 11:30 “Refugee Resettlement” David Delacretaz, Scott Duke Kominers, and Alexander Teytelboym
11:30 - 11:55 “Matching Problem of Civil Service”Ashutosh Thakur
11:55 - 12:20 “Trading  Networks  with  General  Preferences” Jan  Christoph Schlegel
12:20 - 13:45    Lunch
13:45 - 14:30    Invited Talk “International Kidney Exchange Programmes:  Op-timisation and Games”Peter Biro
14:30 - 14:55 “Pareto Optimal Coalitions of Fixed Size” ́Agnes Cseh,  Tam ́as Fleiner, and Petra Harjan 
14:55 - 15:20 “Balanced Stable Marriage:  How Close is Close Enough?” Sushmita Gupta, Sanjukta Roy, Saket Saurabh, and Meirav Zehavi
15:20 - 15:50    Coffee Break
15:50 - 16:15“Flexibility in House Allocation and Housing Markets” Madhav Raghavan
16:15 - 16:40 “Endowment Manipulations in Probabilistic Assignment Problem”Yuki Tamura
16:40 - 17:05“Equivalent   Choice   Functions   and   Stable   Mechanisms” Jan Christoph Schlegel
17:05 - 17:15    Short Break (no coffee)
17:15 - 17:40 “Centralized  Matching  with  Incomplete  Information” Marcelo Ariel Fernandezand Leeat Yariv
17:40 - 18:05“Simultaneous  Search:   Beyond  Independent  Successes” Ran  I.Shorrer
18:05 - 18:30 “Deferred Acceptance and Regret-free Truth-telling:  A Character-ization Result” Marcelo Ariel Fernandez

 Tuesday, May 28

09:00 - 09:45    Invited  Talk “Balanced  Exchange  in  a  Multi-Object  Shapley-Scarf Market” P ́eter Biro,Flip Klijn, and Szilvia Papai
09:45 - 10:10 “Competing for Priorities in School Choice” Greg Leo and MartinVan der Linden
10:10 - 10:35 “Information  Acquisition  Costs  in  Matching  Markets”  Nicole  S. Immorlica, Jacob D. Leshno, and Irene Y. Lo
10:35 - 11:05    Coffee Break
11:05 - 11:30 “Efficient and (Pretty) Fair Course Assignment with Quotas” Martin  Bichler,  Alexander  Hammerl,  Thayer  Morrill,  and StefanWaldherr
11:30 - 11:55 “An Algorithm for Strong Stability in the Student-Project Alloca-tion Problem with Ties” Sofiat Olaosebikan and David Manlove
11:55 - 12:20“Strategy-Proof  Approximation  Algorithms  for  the  Stable  Mar-riage  Problem  with  Ties  and  Incomplete  Lists”,  Koki  Hamada, Shuichi Miyazaki, and Hiroki Yanagisawa

Wednesday, May 29th
09:00 - 09:45    Invited  Talk “Efficient  and  Incentive-Compatible  Liver  Ex-change” Haluk Ergin, Tayfun Sonmez, andM. Utku Unver
09:45 - 10:10 “Matching  for  the  Israeli  “Mechinot”  Gap-Year  Programs:  Handling Rich Diversity Requirements” Yannai A. Gonczarowski, Lior Kovalio, Noam Nisan, and Assaf Romm
10:10 - 10:35 “Recourse in Kidney Exchange Programs” Valentin Bartier, Yves Crama, Bart Smeulders, and Frits C.R. Spieksma
10:35 - 11:05    Coffee Break
11:05 - 11:30 “Obvious Dominance and Random Priority” Marek Pycia and Peter Troyan
11:30 - 11:55 “Subgame Perfect Equilibria under the Deferred Acceptance Algo-rithm” Keisuke Bando andYasushi Kawase
11:55 - 12:20 “Optimizing Reserves in School Choice:  A Dynamic ProgrammingApproach” Franklyn  Wang,  Ravi  Jagadeesan,  and  Scott  Duke Kominers
12:20 - 13:45    Lunch
13:45 - 14:10 “Strategy-proof,  Envy-free  and  Pareto  Efficient  Online  Mecha-nisms for Fair Division with Additive Valuations” Martin Aleksandrov and Toby Walsh
14:10 - 14:35 “An Alternative Approach to Asylum Assignment” Gian Caspari
14:35 - 15:00 “Matching  with  Myopic  and  Farsighted  Players” Jean-Jacques Herings, Ana Mauleon, and Vincent Vannetelbosch
15:00 - 15:30    Coffee Break
15:30 - 16:15    Invited Talk “Pareto Optimal Allocation under Uncertain Pref-erences” Haris Aziz,  Peter Bir ́o,  Ronald de Haan,  and Baharak Rastegari
16:15 - 16:40    CSF Award and Algorithms Award
16:40 - 18:00    Poster Presentation Session 2A
ll papers as in Poster Presentation Session 1 (except for Jonah Peranson and Christian Haas).

Friday, May 24, 2019

Matching early when information is costly, by Grenet, He, and Kübler

Here's a new paper on school matching that takes preference formation seriously:

Decentralizing Centralized Matching Markets:
Implications from Early Offers in University Admissions
by Julien Grenet, Yinghua He, and Dorothea Kübler
May 2019

 The matching literature commonly rules out that market design itself shapes agent preferences. Underlying this premise is the assumption that agents know their own preferences at the outset and that preferences do not change throughout the matching process. This assumption implies that a centralized market where agents receive at most one offer can dominate a decentralized market where multiple offers to agents are possible. Using a quasi-experiment in Germany’s university admissions, we provide evidence against this assumption. We study a centralized clearinghouse that implements the early stages of the university-proposing Gale-Shapley deferred-acceptance mechanism in real time, resembling a decentralized market with continuous offers, rejections, and acceptances. With data on the exact timing of every decision, we show that early offers are more likely to be accepted than (potential) later offers, despite early offers not being made by more desirable universities. Furthermore, early offers are only accepted after some time rather than immediately. These results and direct survey evidence are consistent with a model of information acquisition: it is costly for students to learn about universities and accepting a university that turns out to be inferior causes regret. We discuss and rule out some alternative hypotheses. Our findings motivate a hybrid mechanism that balances centralization and decentralization. By allowing sequential learning, it improves welfare, especially in markets with substantial learning costs.

Thursday, May 23, 2019

Vic Fuchs on the problems of employment-based health insurance, in JAMA

Vic Fuchs, the dean of American health economists, argues that employment-based insurance has an assortment problem focused on high income consumers (he compares it to Whole Foods versus Walmart) and a related high cost of administration.

May 9, 2019
Does Employment-Based Insurance Make the US Medical Care System Unfair and Inefficient?
Victor R. Fuchs, JAMA. Published online May 09, 2019. doi:10.1001/jama.2019.4812

"In the United States, the interests of high-income individuals dominate decisions about what medical care is offered and how it is financed. The result is a less efficient and less equitable medical care system than in other high-income countries. Employment-based insurance plays a key role in determining the production and financing of US medical care.
"Emphasis is on specialty and subspecialty care, expensive technology, extra capacity to facilitate access (US hospitals have an average occupancy rate of 65% compared with an average of 76% according to the Organisation for Economic Co-operation and Development), and more and better-quality amenities, including space and privacy in the hospital.3 Architects who build in many countries suggest that design for US hospitals must also include better space for visitors and professional staff. This more costly product mix (specialty care and hospital amenities) is appreciated by patients at all income levels, but higher-income patients would and sometimes do pay extra for them. Many low- and middle-income households would be better off if medical care was less costly, and they had more money for other public and private goods and services.
"The preference of high-income patients for a costly product mix also adversely affects the efficiency of research and development in the choice of projects because market size influences the direction of investment in innovation. Almost all private medical research and development is directed toward extending the product mix with few attempts to discover new lower-cost interventions with truly disruptive innovations. The interests of high-income patients not only result in inefficiency in medical care production and innovation, but also adversely affect the way the United States finances health care. The present system, which is a mix of employment-based insurance, other private insurance, numerous government programs, including Medicaid and Medicare, each with its own eligibility rules and payment schemes, and out-of-pocket payments, is extremely costly to administer.4,5 The large role played by private insurance in the United States helps high-income households because the price of the insurance is the same regardless of income, whereas government plans typically require higher-income individuals to pay a larger share of the nation’s medical care bill."

Wednesday, May 22, 2019

Kidney exchange in India: the legal framework

Last week in Ahmedabad I had a chance to interact with Dr. Vivek Kute and his colleagues at the Trivedi Institute, to better understand the setting of their innovative kidney exchange program.  The legal framework is of course a big part of that environment.

Here's India's Transplantation of Human Organs and Tissues Act (THOA), 2014 (scroll down for the English language version).

As in other places, much of the law is shaped by  repugnance towards kidney sales. To this end, the law requires that an Authorisation Committee approve donation from someone who is not a "near relative," in the immediate nuclear family.

"Authorisation Committee.
(3) When the proposed donor and the recipient are not near relatives, the Authorisation Committee shall,- 
(i)evaluate that there is no commercial transaction between the recipient and the donor and that no payment has been made to the donor or promised to be made to the donor or any other person; 
(ii)prepare an explanation of the link between them and the circumstances which led to the offer being made;"

In the case of kidney exchange, only a near relative may serve as the intended donor (i.e. no uncles, aunts, cousins, etc.).

"(4)Cases of swap donation referred to under subsection (3A) of section 9 of the Act shall be approved by Authorisation Committee of hospital or district or State in which transplantation is proposed to be done and the donation of organs shall be permissible only from near relatives of the swap recipients."

The present law also does not allow nondirected donors.

Here are some related earlier posts:

Tuesday, May 21, 2019 Robot-assisted kidney transplantation in Ahmedabad, India.

Monday, July 2, 2018

Tuesday, May 21, 2019

Robot-assisted kidney transplantation in Ahmedabad, India.

I just returned from a very interesting visit to Ahmedabad, Gujarat, India, part of which was at the Trivedi Institute of Transplantation Sciences. There I had the privilege of sitting in on a robot-assisted kidney transplant operation conducted by Dr. Pranjal Modi. In the picture below, Dr. Modi is seated at the robot, that he operates with his hands and feet, while I watch on a screen, behind which is the patient (surrounded by doctors maintaining the various instruments inside him, through small incisions).

Dr. Pranjal R. Modi at the robot controls, while I watch him perform a kidney transplant.

Below is the two-dimensional image in which I followed what he was doing (but when he looks through the binoculars of the robot, he sees it in very clear 3 dimensions).

The high magnification is apparently a big aid to fast and precise surgery, which (together with small incisions) is one of the attractions of robotic surgery.

The robot was made by Da Vinci.
I think this is the patient-facing part of the particular robot being used:

Monday, May 20, 2019

Management Science’s 65th Anniversary Conference, May 20-21, Boston University

Management Science’s 65th Anniversary Conference
May 20 – 21, 2019
Boston University Questrom School of Business

"2019 marks the publication of the 65th volume of Management Science. To celebrate this anniversary, the editorial board is organizing a conference at Questrom School of Business, Boston University, from May 20th to May 21st, 2019. The focus of the conference is “Innovations in the Science and Practice of Management,” with an emphasis on integrating theory and practice. "

Here's the conference program.  It appears it will be a single stream, without parallel sessions.

It includes some talks explicitly labelled as market design, including, on Monday,
10:30 – 11:15 am Market Design, Behavioral and Experimental Economics and Management
Prof. Yan Chen, University of Michigan
Prof. Peter Cramton, University of Maryland
Prof. Axel Ockenfels, University of Cologne

And my talk on Tuesday,
Operational aspects of market design: the case of kidney exchange
By Itai Ashlagi and Al Roth

Sunday, May 19, 2019

Gail Cornwall responds to the recent NY Times story on SF schools

Gail Cornwall, who follows San Francisco schools, replies to a recent article in the NY Times:

A cautionary tale about linking school choice and segregation

"Late last month, New York Times’ national education reporter Dana Goldstein wrote about public school choice and segregated schools in San Francisco. Headlined San Francisco Had an Ambitious Plan to Tackle School Segregation. It Made It Worse, the story hits several nails squarely on the head.
"But there are several important weaknesses in Goldstein’s article that could mislead parents, readers, and policymakers.
"The piece lays blame for segregation at the feet of San Francisco’s citywide public school choice system. It oversimplifies the views and priorities of lower-income non-white families. And, though Goldstein told me it wasn’t meant to, the article seems to endorse a controversial return to a restriction of choice in favor of a form of neighborhood attendance zones."

Here's my earlier post on the NY Times article:

Tuesday, May 7, 2019

I've blogged about other articles by Ms. Cornwall.

Saturday, May 18, 2019

Yale SOM celebrates Vahideh Manshadi on the benefits of scale in kidney exchange

In Yale Insights (from Yale SOM):

Kidney Exchange Registries Should Collaborate to Save More Lives

"The results were surprising, says Manshadi. “We didn’t find any evidence that higher-frequency match runs were reducing the overall number of transplants by depleting the pool of potential donors. The total number of transplants remained stable.”

"What the researchers did find, however, was an unexpectedly high number of patients in both programs whose antibodies made them hard to match—what are called sensitized patients.

“The majority of patients in these programs are sensitized,” Manshadi says. “These patients have such high levels of antibodies in their blood that they are more likely to reject a donor organ. Frequent or infrequent matching will have little effect on them because it’s so much harder to find a donor whose kidney they can accept.”

"The best way of improving the outlook for these patients, says Manshadi, is to ensure they are prioritized when searching for matches. That, and find new ways of increasing—and diversifying—the number and range of donors coming into exchange programs. "

And here's the original paper:

Effect of match‐run frequencies on the number of transplants and waiting times in kidney exchange
Itai Ashlagi  Adam Bingaman  Maximilien Burq  Vahideh Manshadi  David Gamarnik  Cathi Murphey  Alvin E. Roth  Marc L. Melcher  Michael A. Rees, American Journal of Transplantation, Volume18, Issue5, May 2018, Pages 1177-1186
First published: 31 October 2017

Numerous kidney exchange (kidney paired donation [KPD]) registries in the United States have gradually shifted to high‐frequency match‐runs, raising the question of whether this harms the number of transplants. We conducted simulations using clinical data from 2 KPD registries—the Alliance for Paired Donation, which runs multihospital exchanges, and Methodist San Antonio, which runs single‐center exchanges—to study how the frequency of match‐runs impacts the number of transplants and the average waiting times. We simulate the options facing each of the 2 registries by repeated resampling from their historical pools of patient‐donor pairs and nondirected donors, with arrival and departure rates corresponding to the historical data. We find that longer intervals between match‐runs do not increase the total number of transplants, and that prioritizing highly sensitized patients is more effective than waiting longer between match‐runs for transplanting highly sensitized patients. While we do not find that frequent match‐runs result in fewer transplanted pairs, we do find that increasing arrival rates of new pairs improves both the fraction of transplanted pairs and waiting times.

Friday, May 17, 2019

Repugnant phrasing

Japan's labor and immigration policies have been more restrictive than welcoming to an immigrant/migrant labor force.  So one can imagine a cheerful headline saying that was about to change, something along the lines of the final paragraph quoted below.  I don't think the following WSJ headline quite does the trick:

Japan Aims to Hire Foreigners for Nuclear Cleanup
The country’s largest utility is working to decommission the Fukushima plant amid radiation risks at the site of the 2011 disaster

"TOKYO—Japan’s largest utility is looking to foreign blue-collar workers to help decommission its Fukushima Daiichi nuclear-power plant amid a labor shortage exacerbated by radiation risks at the site of the 2011 nuclear disaster.

"Tokyo Electric Power Co. , or Tepco, said Thursday it has informed dozens of contractors that foreigners could qualify for a new type of visa that allows manual workers to stay in the country for five years. Workers who enter areas with elevated radiation would need sufficient Japanese-language skills to comprehend radiation levels and safety instructions, a Tepco spokeswoman said.

"The move is a shift in strategy for Tepco, which hasn’t employed large numbers of blue-collar foreigners at the Fukushima plant. As of February, there were 29 foreign workers, the spokeswoman said.

"Under a new law that went into effect this month, Japan plans to open its doors to about 340,000 workers over the next five years to help fill job vacancies in chronically understaffed industries such as construction and nursing care. The new law also creates another type of visa for higher-skilled blue-collar workers who can stay indefinitely."

Thursday, May 16, 2019

Market design workshop, NBER October 18-19, 2019 in Cambridge.

Here's the call for papers

To:     NBER Market Design Working Group
From:   Michael Ostrovsky and Parag Pathak

The National Bureau of Economic Research workshop on Market Design is
a forum to discuss new academic research related to the design of
market institutions, broadly defined.
The next meeting will be held in Cambridge, MA on October 18 & 19, 2019.

We welcome new and interesting research, and are happy to see papers
from a variety of fields. Participants in the past meeting covered a
range of topics and methodological approaches.
Last year's program can be viewed at:

The conference does not publish proceedings or issue NBER working
papers - most of the presented papers are presumed to be published
later in journals.

There is no requirement to be an NBER-affiliated researcher to
participate. Younger researchers are especially encouraged to submit papers.

If you are interested in presenting a paper this year, please upload
a PDF version by August 1, 2019 to this link:

Preference will be given to papers for which at least a preliminary
draft is ready by the time of submission. Only authors of accepted
papers will be contacted.

For presenters in North America, the NBER will cover the travel and
hotel costs. For speakers from outside North America, while the NBER
will not be able to cover the airfare, it can provide
support for hotel accommodation.

There are a limited number of spaces available for graduate students
to attend the conference, though we cannot cover their costs. Please
email a short nominating paragraph.

Please forward this announcement to any potentially interested
scholars. We look forward to hearing from you.

Wednesday, May 15, 2019

Finding out what employers value in a candidate, without deception, by Kessler, Low and Sullivan

Many experiments designed to detect how employers evaluate applications employ deception: artificial applications are sent to employers in response to advertisements of job openings, and the responses are recorded. This involves deception (to get employers to devote resources to fake applications).  Here's a design that seeks the same information without deception.

Incentivized Resume Rating: Eliciting Employer Preferences without Deception

Judd B. KesslerCorinne LowColin Sullivan

NBER Working Paper No. 25800
Issued in May 2019 
"We introduce a new experimental paradigm to evaluate employer preferences, called Incentivized Resume Rating (IRR). Employers evaluate resumes they know to be hypothetical in order to be matched with real job seekers, preserving incentives while avoiding the deception necessary in audit studies. We deploy IRR with employers recruiting college seniors from a prestigious school, randomizing human capital characteristics and demographics of hypothetical candidates. We measure both employer preferences for candidates and employer beliefs about the likelihood candidates will accept job offers, avoiding a typical confound in audit studies. We discuss the costs, benefits, and future applications of this new methodology."

Tuesday, May 14, 2019

Randomization in Economics: a history, by Julian Jamison

Randomized experiments have a long history:

By:Julian C. Jamison
Volume: 7,  
Issue: 1 MAR 2019

Although the concept of randomized assignment in order to control for extraneous confounding factors reaches back hundreds of years, the first empirical use appears to have been in an 1835 trial of homeopathic medicine. Throughout the 19th century there was a growing awareness of the need for comparison groups, albeit often without the realization that randomization could be a clean method to achieve that goal. In the second and more crucial phase of this history, four separate but related disciplines introduced randomized control trials within a few years of one another in the 1920s: agricultural science; clinical medicine; educational psychology; and social policy (specifically political science). This brought increasing rigor to fields that were focusing more on causal relationships. In a third phase, the 1950s through 1970s saw a surge of interest in more applied randomized experiments in economics and elsewhere - both in the lab and especially in the field.

Monday, May 13, 2019

PBS on Uber's economists

Paul Solman interviews Uber economists (John Hall and others) and other economists (Susan Athey and Paul Oyer) on what economists do at Uber:

Sunday, May 12, 2019

UNOS proposal for public comment: Eliminate the use of DSAs and regions from kidney and pancreas distribution

Public comment solicitation is a lengthy process--and this proposal has solicited many lengthy comments (for which you'll have to scroll down at the link...)

Proposal Overview

Status: Public Comment
Sponsoring Committee: Kidney Transplantation Committee & Pancreas Transplantation Committee
Strategic Goal 2: Provide equity in access to transplants
Read the concept paper (PDF; 1/2019)
Contacts: Scott Castro and Abigail Fox
Data request from the OPTN Kidney Transplantation CommitteeProvide simulation data on effect of removing DSA and region from kidney/pancreas/kidney-pancreas organ allocation policy

Executive summary

The Final Rule (hereafter “Final Rule”) sets requirements for allocation polices developed by the Organ Procurement and Transplantation Network (OPTN) and the United Network for Organ Sharing (UNOS), including the use of sound medical judgement, achieving the best use of organs, preserving the ability for centers to decide whether to accept an organ offer, avoiding wasting organs, avoiding futile transplants, promoting patient access to transplantation and promoting efficiency. The Final Rule also includes a requirement that policies “shall not be based on the candidate’s place of residence or place of registration, except to the extent required” by the other requirements of the Final Rule.
In the past year, the United States Secretary of Health and Human Services (HHS) received critical comments regarding the OPTN/UNOS’s compliance with the National Organ Transplant Act (NOTA) and the Final Rule with respect to the geographic units used in lung and liver distribution. The OPTN/UNOS made rapid changes to eliminate using donation service area (DSA) and OPTN/UNOS regions (regions) in lung and liver distribution, respectively. Furthermore, the OPTN/UNOS Executive Committee directed the organ-specific committees to analyze their distribution systems and replace DSAs and regions with more rational units of distribution.
Policy 8: Allocation of Kidney and Policy 11: Allocation of Pancreas, Kidney-Pancreas, and Islets currently use DSA and region as geographic units of distribution. These are poor proxies for geographic distance between donors and transplant candidates because the disparate sizes, shapes, and populations of DSAs and regions result in an inconsistent application for all candidates. As noted in Department of Health and Human Services Administrator Sigounas’s letter to the OPTN/UNOS President, “DSAs and Regions have not and cannot be justified” under the regulatory requirements of the Final Rule.
Members of the OPTN/UNOS Kidney Transplantation Committee, joined by members from the OPTN/UNOS Pancreas Transplantation Committee and the OPTN/UNOS Pediatric Transplantation Committee, created the Kidney/Pancreas Workgroup (hereafter “the Workgroup”) in order to remove DSA and region from kidney and pancreas allocation policies. The Workgroup reviewed OPTN/UNOS data on current distribution practices, engaged Workgroup members on their collective clinical experience, and utilized the OPTN/UNOS Board of Directors’ “Geographic Organ Distribution Principles and Models” to develop five potential allocation options that would eliminate DSA and region from kidney and pancreas allocation policies.
The five variations that the Workgroup chose to model are:
  1. A fixed concentric circle framework with a 150 nautical mile (NM) small circle and a 300 NM large circle
  2. A fixed concentric circle framework with a 250 NM small circle and a 500 NM large circle
  3. A fixed concentric circle framework with a single 500 NM circle
  4. A hybrid framework with a single 500 NM circle that utilizes a small number of proximity points inside and outside of the circle, and
  5. A hybrid framework with a single 500 NM circle that utilizes a large number of proximity points inside and outside of the circle.
These variations will be more comprehensively outlined in this paper’s “What Concepts Are Being Considered?” section. The Workgroup is not limiting itself to consideration of solely these five variations, but rather used these variations as choices to model in the Kidney/Pancreas Simulated Allocation Model (KPSAM) in order to most strategically determine what could be the ideal variation. The Workgroup understands that, given community feedback and additional evidence gathered, it is possible that the framework and variation ultimately selected by the Workgroup may be a combination of these variations, or perhaps a new variation, such as a single-circle hybrid with a smaller concentric circle.
The Workgroup is currently considering these five variations for modifying kidney and pancreas allocation policy to be more consistent with the Final Rule and to provide more equity in access to transplantation regardless of a candidate’s place of residence or registration, except to the extent required by §121.8 (a)(1)-(5) of the Final Rule. The Workgroup requests community feedback in order to better inform the evidence-gathering and decision-making processes.

Feedback requested

Saturday, May 11, 2019

How are American transplant centers regulated? How does this influence treatment decisions?

Here's a NYT oped about the fact that transplant centers are regulated based on their one-year graft survival statistics--i.e. on how often the transplant (and the patient) lasts 12 months:

When Is a Transplant Worth It?
A year in a hospital bed is a “success” while dying after 11 months is failure.
By Daniela J. Lamas
Dr. Lamas is a pulmonary and critical care physician.

"The single-minded focus on staying alive for a year begins at the time of a transplant program’s initial certification by the Centers for Medicare and Medicaid Services. If the program’s one-year mortality rate is higher than expected, possibly because surgeons are giving transplants to people who are too sick, that program could be put on probation or lose its certification. That metric is equally important to the United Network for Organ Sharing, which allocates donor organs. A patient looking for information might happen upon the Yelp-style transplant center rankings developed by the Scientific Registry of Transplant Recipients — also based on one-year mortality, particularly for lung transplant programs.
"The focus on one-year mortality isn’t necessarily what patients want, and it can have unintended consequences. Dr. Richard Formica, a kidney transplant specialist at Yale-New Haven Hospital, noted that with mortality as the metric of success, surgeons might be apt to discard riskier transplant organs because they worry about their numbers. The concern about program numbers — and the potential repercussions for other patients if a center loses its certification — also might influence the choice of who gets a transplant in the first place. “Do we deny patients who have an increased risk of mortality in the first year?” Dr. Formica asked. “Yes, we do.”

Friday, May 10, 2019

Indian Society of Organ Transplantation meeting in Ahmedabad May 11-12

I'll be in Ahmedabad this weekend, starting with a conference of the Indian Society of Transplantation:

Here's a draft of the program.

My two talks will be on
History and organization of kidney exchange, and
Taboo transactions and frontiers in ethical kidney exchange

Thursday, May 9, 2019

Shrouded prices for blood tests in the U.S.

One of the features of the American health care system is that prices are heavily shrouded--insurance companies reach negotiated prices with providers, that may be very different with different providers, and very different from list prices, and are not quoted. So prices aren't nearly as informative in health care as in most other markets.

Here's a NYT story that focuses on blood tests:

They Want It to Be Secret: How a Common Blood Test Can Cost $11 or Almost $1,000
Huge price discrepancies like that are unimaginable in other industries. Also unusual: not knowing the fee ahead of time.

Wednesday, May 8, 2019

David Kreps on Behavioral Economics (Nemmers Prize Lecture)

David Kreps won the 2018 NEMMERS PRIZE IN ECONOMICS , and
today, at Northwestern, he is giving his



Behavioral economics is generally taken to mean economics in which the behavior of individual agents does not conform to the “standard model” of rational behavior.  However, under this banner, one finds a very large number of specific “nonstandard” models of behavior.  This very large number prompts a standard criticism of behavioral economics:  If any behavior is permissible, any conclusion can be reached.  
Using a small handful of examples, the lecture illustrates and fleshes out a test for the value of work in behavioral economics.  This test is based on three principles:
  1.  Is the behavior in the model systematic, at least in some important contexts?
  2. Does positing this behavior lead to economically significant phenomena?
  3. Either via intuition or, preferably, empirical evidence, does the behavior provide "better" explanations of those significant phenomena, where defining the adjective “better” is the crux of the matter.

Tuesday, May 7, 2019

School choice in San Francisco--update in the NYT

Here's the NY Times story: San Francisco Had an Ambitious Plan to Tackle School Segregation. It Made It Worse.

“Our current system is broken,” said Stevon Cook, president of the district Board of Education, which, late last year, passed a resolution to overhaul the process. “We’ve inadvertently made the schools more segregated.”
"About a quarter of the city’s children are enrolled in private school, a higher percentage than in some other major cities, like New York, where it is around 20 percent. The lottery system is thought to be a major reason wealthy parents here opt out of public schools, further worsening segregation."

The San Francisco Unified School District interacted with market designers some years ago, but ultimately turned down their (our) help and decided to deal with the existing problems in-house.  Here are some old blog posts...

Thursday, September 23, 2010

Thursday, June 2, 2011

Monday, May 6, 2019

A (first) liver-kidney exchange

Here's a forthcoming paper in the American Journal of Transplantation:

Bi‐organ Paired Exchange – Sentinel Case of a Liver‐Kidney Swap
by Ana‐Marie Torres  Finesse Wong  Janine Sabatte‐Caspillo  Sandy Del Grosso John P Roberts  Nancy L Ascher  Chris E Freise  Brian K Lee
First published: 12 April 2019

Abstract: "Organ transplantation is the optimal treatment for patients with ESLD and ESRD. However, due to the imbalance in the demand and supply of deceased organs, most transplant centers worldwide have consciously pursued a strategy for living donation. Paired exchanges were introduced as a means to bypass various biologic incompatibilities (blood‐ and tissue‐typing), while expanding the living donor pool. This shift in paradigm has introduced new ethical concerns that have hitherto been unaddressed, especially with non‐directed, altruistic living donors. So far, transplant communities have focused efforts on separate liver‐ and kidney‐paired exchanges, whereas the concept of a trans‐organ paired exchange has been theorized and could potentially facilitate a greater number of transplants. We describe the performance of the first successful liver‐kidney swap."
The discussion of the ethical concerns mentioned in the abstract strike me as worth looking at, given that one of the authors, when she was president of the Transplantion Society, argued strenuously that poor patients should not be allowed to participate in American kidney exchange, for ethical reasons.

First, here are the practical steps they took:
"Our team debated the ethical underpinning of this swap. A discussion with the chair of the ethics committee at the time concluded that a full committee review was unnecessary."

Second, they considered the differential risks to the kidney and liver donors, and decided that this did not disallow the donations, since both kidney and liver donation is already accepted.

Finally they discuss the differential benefits to the liver and kidney recipients:
"Another area of contention is that donor-L’s recipient received remarkably less from a “life-enhancing” kidney transplant (rather than a truly “life-saving” liver transplant), despite the fact donor-L took on the substantially greater risk of donor hepatectomy. Our counterpoint is that the kidney recipient was spared from an extended dependency on dialysishad she stayed on the deceased donor waitlist (mortality on the kidney wait-list is 6-8% annually with a significant reduction in quality of life15,16). This does not even account for the superior allograft and patient survival outcomes that comes with a living vs. a deceased donor kidney transplant17. In fact, Merion18made the observation that the risk to patients on the kidney waitlist is not dissimilar to the liver waitlist mortality and reduction in quality of life for those with moderate MELD scores of 12-17. "

Fortunately for the patients involved, they decided that the benefits to the liver and kidney recipients were comparable. The implication is that if they had decided that the 'life-saving' benefits of a liver exceeded the 'life-enhancing' benefits of the kidney, then the exchange would have been unethical, and the ethical course of action would have been not to go ahead with it--which would likely have resulted in a quick death sentence for the liver patient, and perhaps a slower one for the kidney patient.

I'm glad that the dire decree was diverted.

It is this kind of ethical reasoning that led one of the authors to conclude that it would be unethical to go ahead with global kidney exchanges involving patient-donor pairs whose care had to be financed outside of their own countries' insurance coverage, so that, ethically, they could not be offered treatment even when financing was available. (It's lucky that the patients in this liver-kidney exchange apparently had good insurance, too.)
The paper has an interesting back story in some speculative thoughts on market design.

The second reference in the paper is to a paper by computer scientists John Dickerson at Maryland and Tuomos Sandholm at CMU, proposing that multi-organ exchanges might substantially increase transplantation:
 Dickerson J, Sandholm T. Liver and multi-organ exchange. Journal of Artificial Intelligence Research. 2017;60:639

An unusual twist to the story is that it is the liver donor, eager to help her mother get a kidney transplant, who read the Dickerson-Sandholm paper and proposed the idea to the docs at UCSF.

Here's a press release from CMU, celebrating the event, and Sandholm's contributions:
Computer Science Idea Triggers First Kidney-Liver Transplant Swap
Sandholm says multi-organ exchanges could boost number of transplants

Update: here's a May 11 story in the Washington Post

Sunday, May 5, 2019

Do child labor laws apply to social media?

The Guardian asks the question:
'It's not play if you're making money': how Instagram and YouTube disrupted child labor laws

"while today’s child stars can achieve incredible fame and fortune without ever setting foot in a Hollywood studio, they may be missing out on one of the less glitzy features of working in the southern California-based entertainment industry: the strongest child labor laws for performers in the country.

"Those laws, which were designed to protect child stars from exploitation by both their parents and their employers, are not being regularly applied to today’s pint-sized celebrities, despite the fact that the major platforms, YouTube and Instagram, are based in California. The situation is a bit like “Uber but for … child labor”, with a disruptive technology upending markets by, among other things, side-stepping regulation."

Saturday, May 4, 2019

Global kidney health atlas from the International Society of Nephrology

Here's the 2019 Global Health Atlas

Kidney transplantation is nowhere readily available to everyone who needs it,  but the wealthy countries of the West provide it most widely:

Annual costs of dialysis are roughly the same as costs of transplantation in the year the transplant is performed (and of course dialysis costs stay roughly constant until the patient dies or is transplanted, while the costs of a successful transplant become largely the costs of immunosuppressive drugs).

Friday, May 3, 2019

Donating eggs for fertility: an update

Slate brings us up to date:


"The first US child conceived from a donated egg was born in 1984. Since then, the procedure has grown into a thriving industry. Demand from aspiring parents, along with a dearth of regulations, have spawned matchmaking agencies that offer to help parents find the perfect young woman whose eggs will result in the equally perfect child.

"Donating eggs can be lucrative, with agencies paying as much as $50,000 per cycle in some cases.
"Ads or marketing materials targeting potential donors rarely mention the risks or common complaints. Liz Scheier donated eggs three times between 2005 and 2007, and says she was told there were no known risks associated with egg donation. Today, Scheier is a media liaison for We Are Egg Donors, a women’s health organization that works with more than 1,500 donors to promote transparency and advocate for their concerns. She says that donors nowadays hear the same line she did, delivered almost verbatim. But it’s missing one key detail. “There are no known risks because no one has looked,” she adds.
"Egg donation has thrived in the US in part because there are few laws regarding the transfer of unfertilized eggs for reproductive purposes, according to industry experts. They say a handful of states have policies that touch on some aspect of egg donation, generally from the perspective of the recipient.

With few regulations, the US has become a magnet for well-off wannabe parents in other countries where egg donation is regulated, or outright illegal. Egg donation is barred in China, Germany, Italy, and Norway; paying women to donate eggs is prohibited in most of Europe, as well as in Canada and other nations.
"In 2011, an egg donor sued ASRM [American Society for Reproductive Medicine] over the organization’s compensation guidelines, which the donor claimed were a form of illegal price-fixing; other donors later joined the case. In a 2016 settlement, ASRM agreed to eliminate its payment suggestions, pay $1.5 million in legal fees, and give the plaintiffs $5,000 each. Agencies were freer to offer donors more money.
"Since then, donor pay has soared, particularly for attractive, well-educated donors."

HT: Stephanie Lo

Thursday, May 2, 2019

Legal marijuana in California struggling to compete with the well established black market

Yesterday I posted about the competition the legal market for marijuana in Canada is facing from the pre-existing illegal market. Today we turn to California. It's still to early to draw conclusions, but one market design lesson is that even if the attraction of a legal market is regulation and tax revenue, regulators and tax authorities may have to ease up at least in the beginning if they want the legal market to out-compete the legacy black market.

In the NY Times, Thomas Fuller has been following the market(s):

‘Getting Worse, Not Better’: Illegal Pot Market Booming in California Despite Legalization  By Thomas Fuller

"It’s been a little more than a year since California legalized marijuana — the largest such experiment in the United States — but law enforcement officials say the unlicensed, illegal market is still thriving and in some areas has even expanded.
"The struggles of the licensed pot market in California are distinct from the experience of other states that have legalized cannabis in recent years. Sales in Colorado, Oregon and Washington grew well above 50 percent for each of the first three years of legalization, although Oregon now also has a large glut of pot.

"But no other state has an illegal market on the scale of California’s, and those illicit sales are cannibalizing the revenue of licensed businesses and in some cases, experts say, forcing them out of business.
"California gives cities wide latitude to regulate cannabis, resulting in a confusing patchwork of regulation. Los Angeles, San Francisco, San Jose and San Diego have laws allowing cannabis businesses, but most smaller cities and towns in the state do not — 80 percent of California’s nearly 500 municipalities do not allow retail marijuana businesses. The ballot measure legalizing recreational marijuana passed in 2016 with 57 percent approval, but that relatively broad support has not translated to the local level. Cities like Compton or Laguna Beach decisively rejected allowing pot shops.

"Regulators cite this tepid embrace by California municipalities as one of many reasons for the state’s persistent and pervasive illegal market. Only 620 cannabis shops have been licensed in California so far. Colorado, with a population one-sixth the size of California, has 562 licensed recreational marijuana stores.
"And the monetary incentives of trafficking also remain powerful: The price of cannabis products in places like Illinois, New York or Connecticut are typically many times higher than in California."