The former governor of Indiana is pleasantly surprised by Harvard

 Eric Holcomb taught a seminar at Harvard after stepping down as governor of Indiana.  He reports that he expected to find a woke hell, but instead found a thriving university.  He attributes that in part to President Trump's war on American universities in general and on Harvard in particular.

I was a red state governor. What I saw at Harvard surprised me.
The spirit of association remains alive in unexpected places.   By Eric Holcomb
Eric Holcomb, a Republican, was the governor of Indiana from 2017 to 2025.

"In January, I completed two terms as governor of Indiana. This fall, I did what all red state Republicans do (right?): spent a semester teaching at Harvard University. As someone who believes that restoring our communities is among America’s greatest challenges, my goal was to see if the foundation of an open-minded, problem-solving community still existed in a place far removed from my own cultural comfort zone. It does.

...

"I found a community that didn’t always agree but could still talk with each other and work together toward the greater good, which in Harvard’s case includes education, discovery and the development of ideas and technologies.

...

"What I’ve experienced may be a natural return to Harvard’s more moderate bearings, following noisy displays of intolerance by campus agitators in recent years. Or it may be due to the Trump administration’s forceful executive orders and fiscal pressure. Either way (and it’s probably both), let’s take the win and learn the broader lesson." 

Kate Ho (1972-2025)

 Kate Ho has passed away, tragically early.  I met her when she was a grad student at Harvard, who worked with Ariel Pakes.

Here's the Econometric Society announcement:

In Memoriam: Kate Ho 

"We are deeply saddened by the passing of Kate Ho, the John L. Weinberg Professor of Economics and Business Policy at Princeton University and a Fellow of the Econometric Society. Kate was a brilliant IO economist and scholar whose impact on the profession will resonate for many years to come.

Among her numerous achievements, Kate delivered the 2021 Fisher-Schultz Lecture of the Econometric Society and received the 2020 Frisch Medal for the best applied paper published in Econometrica over the previous four years, recognizing her pathbreaking work on contracting and insurer competition in health care markets. She served as Co-Editor of Econometrica from 2021 to 2025, contributing with extraordinary dedication and insight. She was also an elected member of the Council of the Econometric Society from 2021 to 2024 and served on many other Society committees. Beyond her professional excellence, Kate was an exceptionally kind, thoughtful, and collaborative colleague. We will miss her deeply.

We extend our heartfelt condolences to Kate’s family, friends, colleagues, and all who were fortunate enough to know her." 

Kidney exchange updates

 Here are three kidney papers and proposals that I've noted recently,  which will have implications for the growing interest in international kidney exchange on a global scale:

Klaassen MF., de Klerk M, Dor FJ.M.F., Heidt S, van de Laar SC., Minnee RC., van de Wetering J, Pengel LH.M. and de Weerd AE. (2025) Navigating a Quandary in Kidney Exchange Programs: A Review of Donor Travel versus Organ Shipment. Transpl. Int. 38:14804. doi: 10.3389/ti.2025.14804

Abstract:  In multicenter kidney exchange programs (KEPs), either the explanted kidney must be shipped, or the donor must travel to the transplanting center. This review describes the available data on these two approaches and formulates recommendations for practice. We searched for studies addressing organ shipment or donor travel in KEPs. Data were categorized into four domains: cold ischemia time (CIT), logistics, donor/recipient perspectives and professional perspectives. From 547 articles screened, 105 were included. Kidneys are shipped in most countries. Prolonged CIT due to shipment may increase the risk of delayed graft function, but does not seem to impact graft survival. Planning the shipment requires a robust logistical framework with guaranteed operating room availability. Donor travel is reported to be both emotionally and financially distressing for donors and exposes them to inconsistencies in donor evaluation and counseling across centers. Reduced willingness to participate in KEP when travelling was reported by 36%–51% of donors. Professionals generally support offering organ shipment to donors not willing to travel. In conclusion, the decision between donor travel or organ shipment should be tailored to local circumstances. Healthcare professionals should prioritize minimizing barriers to KEP participation, either by facilitating organ shipment or reducing the burden of donor travel. 

######

Neetika Garg, Joe Habbouche, Elisa J. Gordon, AnnMarie Liapakis, Michelle T. Jesse, Krista L. Lentine,
Practical and ethical considerations in kidney paired donation and emerging liver paired exchange,
American Journal of Transplantation,
Volume 25, Issue 11,  2025, Pages 2292-2302,
ISSN 1600-6135,  https://doi.org/10.1016/j.ajt.2025.07.2459.
(https://www.sciencedirect.com/science/article/pii/S1600613525028382)
 

Abstract: Since the first kidney paired donation (KPD) transplant in the United States in 1999, the volume and scope of KPD has expanded substantially, accounting for nearly 20% of living donor kidney transplants in 2021-2022. This review article discusses the practical and ethical issues specific to paired donor exchange that patients, transplant centers, and exchange programs commonly encounter. Access to paired donor exchange and education of candidates regarding the potential benefits, risks, and logistics of KPD are important considerations. Transplant centers and patients must consider practical issues including wait times, allocation and matching strategies, assessment of organ quality, complex donors, cold ischemia time, and risks of broken chains. Protections available to donors from current KPD programs, the potential psychosocial effects, and the ethical concerns related to variable access and the proprietary nature of private exchange programs are also discussed. More detailed, timely data collection at a national level, and ability to merge national data with individual donor exchange registries will enable the analysis of the impact and outcomes of future trends in paired donation. KPD experience and key concepts may inform liver paired exchange, which has been used internationally to expand living donor liver transplantation and is emerging in the United States.

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Alliance for Paired Kidney Donation (APKD) Launches Wish Upon a Donor: A Hope-Focused Advocacy Program Helping Kids Who Need Kidneys Find Living Donors

"TOLEDO, OHIO / ACCESS Newswire / December 9, 2025 / The Alliance for Paired Kidney Donation (APKD) is proud to announce Wish Upon a Donor, a groundbreaking program that amplifies the voices of families fighting for a better and brighter future for their child. While pediatric kidney patients cannot advocate for themselves, their parents can - and too often, they face this battle alone. Wish Upon a Donor helps families share their child's story, shining a light on their hopes, dreams, and urgent need for a living kidney donor.

...

"The onboarding process is fast and simple, taking just 10-15 minutes to complete, and finalized videos are sent to patients in just one to three days. Participation is free, and patients retain full control over how and where their stories are shared.

Wish Upon a Donor offers a range of support for families as they seek living donors, including:

Production of a personalized, high-quality video designed to reflect the patient's wishes, personality, and future - not just their disease

Dedicated campaign webpage to make it easy to convert interest into action

QR-coded postcards and magnets for sharing in local communities

Social media guidance to help families and supporters spread the word

Spanish- and English-language outreach materials for broader access

A living donor mentor to answer any non-medical questions about the process

"Wish buddy" volunteers to assist with video narration and/or sharing patient videos with a broader audience

When interest is generated through the Wish Upon a Donor campaign, APKD ensures both patients and transplant centers are effectively supported with guidance grounded in real-life experience from a dedicated living donor mentor. The organization manages all incoming donor inquiries, educates potential donors on the process, protections, and realities of living donations, and then refers qualified donors to an appropriate transplant center partner. APKD maintains communication and support throughout the evaluation and donation process. This approach empowers potential donors with education while easing the burden on transplant centers."
 

Abortions in the U.S. since state bans have been enacted

 It's hard to effectively ban something that is legal in neighboring jurisdictions.

The NYT has the story:

A Small Illinois City at the Center of a Seismic Shift in Abortion Access. 
Carbondale, Ill., a liberal enclave within driving distance of 10 states with abortion bans, has become a hub for the procedure. Last year there were nearly 11,000 abortions in this city of 21,000.   By Elizabeth Williamson

"Abortion is legal in Illinois, but the state is surrounded by others that have largely banned the procedure in the three years since the Supreme Court overturned Roe v. Wade. As a result, Illinois now leads the nation in out-of-state abortion patients. Carbondale, a college town in Illinois’s southern tip within driving distance of 10 states with abortion bans, has become a major abortion hub.

"Last year three clinics in this city of 21,000 provided close to 11,000 abortions, almost all for women from other states. The numbers, provided by the clinics, account for nearly a third of all out-of-state abortions in Illinois. 

,,,

"The clinics have already drawn protests as well as intervention efforts from Coalition Life, a St. Louis-based anti-abortion group that stations “sidewalk counselors” outside Carbondale’s clinics.

...

"In states without total bans, there were 1,038,100 clinician-provided abortions in 2024, according to the Guttmacher Institute, a research organization that supports abortion rights. The number includes 155,000 abortions for patients who had crossed state lines. Overall, the number of abortions in the country has slightly increased since the Dobbs decision, largely because of medication abortions."

 

Why I Chose to Get E. Coli. — by Josh Morrison

 Josh Morrison is a glutton for (effective) altruism: he's a nondirected kidney donor (who founded the advocacy organization WaitlistZero), and he's an advocate of human challenge trials for vaccines, who founded the organization OneDaySooner.  He reports his own recent experiences as a challenge trial participant, in MedPage Today:

Why I Chose to Get E. Coli. — Human challenge trials can accelerate medical innovation  by Josh Morrison

" challenge trials have been essential for scientific advancements that may not have been possible (or would have taken much longer) with traditional studies. Challenge studies were crucial to developing malaria vaccines. The correlates of protection they established for influenza immunology are still used to license flu vaccines today, and they played an important role in discovering the origins of both ulcers and yellow fever.

"The E. coli vaccine study I joined was at the University of Maryland School of Medicine's Center for Vaccine Development (CVD). Two of my friends had been in studies at the CVD and had positive experiences overall. I felt like the E.coli vaccine in particular was an important one, so I decided it was time for me to participate too.

"To start, half the participants received the first vaccine in the series and half got a placebo. These initial shots and their associated follow-up were part of eight appointments over 3 months. At our appointments, we had our vitals checked and, in some cases, we had our blood collected or received another vaccine. At appointments the week after a vaccination, we'd provide a stool sample. The study culminated in a 9-day quarantine in Baltimore where were we were exposed to the infectious agent: It was time to drink the E. coli.

"The E. coli was suspended in a bicarbonate solution and tasted like Gatorade without the sugar or flavoring. I remember chuckling nervously as I drank it alongside my fellow participants. It was such an odd experience; I felt like an astronaut counting down for liftoff. 

...

"People's motivations for being in the study included the money (about $4,500). But most of my fellow participants were also excited about the chance to be part of important research and were motivated by the novelty of the experience.

...

"

This was the first challenge study I've participated in, despite having been connected to the field for 5 years. I run 1Day Sooner, a nonprofit that advocates on behalf of challenge study volunteers. Some of my colleagues have been challenged in Shigella, Zika, Malaria, COVID, and Salmonella studies. But I never have because I live in New York and I'm not aware of any institutions in New York that run challenge studies. That may sound surprising, but there are only about 30 challenge studies globally each year, and the U.S. is a relative laggard compared to Europe.

"You might be wondering, would I participate in another one? I would, though I'd prefer something outpatient that didn't require a strict quarantine."

 

 

Disagreement in Science: Missing Women by David Klinowski

 Here's an study of women in science that explores a novel angle.

David Klinowski; Voicing Disagreement in Science: Missing Women. The Review of Economics and Statistics 2025; 107 (6): 1743–1753. doi: https://doi.org/10.1162/rest_a_01322 

Abstract: This paper examines the authorship of post-publication criticisms in the scientific literature, with a focus on gender differences. Bibliometrics from journals in the natural and social sciences show that comments that criticize or correct a published study are 20% to 40% less likely than regular papers to have a female author. In preprints in the life sciences, prior to peer review, women are missing by 20% to 40% in failed replications compared to regular papers, but they are not missing in successful replications. In an experiment, I then find large gender differences in willingness to point out and penalize a mistake in someone's work. 

 

 

 

Tom Stoppard (1937 –2025)

 Tom Stoppard, the great English playwright, passed away last week. I saw many of his plays, including his last one, about his apparently late in life discovery that he was Jewish, and that his immediate family had fled Czechoslovakia ahead of  the Nazis, while most of the rest had perished, with a few exceptions.

The play tells the story of three generations of assimilated Jews. You, the audience, of course know how it will end, but they don't, and they are optimistic that their current troubles will soon pass.  It's an eerie feeling to watch that play amidst the world's current uncertainties. 

The NYT tells his story through that final play.

When Tom Stoppard Confronted His Background in His Final Play
The playwright, who learned about his Jewish heritage late in life, addressed it in the Tony Award-winning drama “Leopoldstadt.”   By Marc Tracy

"Stoppard’s final play, too, contained characters whose fates were tragically preordained. The rest is silence."