Artificial breast milk may be on the cellular agriculture horizon

 Cellular agriculture isn't just aspiring to produce meat; now breast milk is queueing up as a (still distant) possibility.

The New Yorker has the story:

Biomilq and the New Science of Artificial Breast Milk. The biotech industry takes on infant nutrition. By Molly Fischer

"New ventures in the world’s oldest food reflect our era’s enthusiasm for tech-based solutions to perennial human problems."

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"The process of making breast milk in a human body begins during pregnancy, when hormonal changes prompt mammary cells to multiply. After delivery, two of the pregnancy hormones—estrogen and progesterone—drop off, while prolactin remains. This spurs the mammary cells to draw carbohydrates, amino acids, and fatty acids from the mother’s bloodstream, and to convert these raw materials into the macronutrients required to feed a baby. In Biomilq’s case, the mammary cells come from milk and breast-tissue samples provided by donors, and the cells multiply in vitro under the care of a team of scientists tasked with keeping them “happy.” The cells are then moved to a hollow-fibre bioreactor—a large tube filled with hundreds of tiny porous tubes that are covered in a layer of the lab-grown cells. As nutrients flow through the small tubes, the cells secrete milk components into the large tube, where they collect.

"Describing the results as “milk components,” not “milk,” is a crucial distinction. Biomilq has demonstrated that its technology can produce many of the macronutrients found in milk, including proteins, complex carbohydrates, and bioactive lipids, but it cannot yet create them in the same ratios and quantities necessary to approximate breast milk. Other elements of breast milk are beyond the scope of the company’s ambition. A mother’s antibodies, for example, are present in her milk, but they aren’t produced by the mammary cells, and, because Biomilq’s product will come from a sterile lab environment, it won’t offer any kind of beneficial gut bacteria.

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"“It’s as fraught as abortion,” Jacqueline Wolf, an emeritus historian of medicine at Ohio University and the author of a history of breast-feeding and formula in the U.S., aptly titled “Don’t Kill Your Baby,” told me. “There’s almost nothing that raises more social issues than infant feeding.” Wolf dates the emergence of what became known as “the feeding question” to the eighteen-seventies, when mothers across the country began raising concerns about their milk supply. “The big change that was sparked by urbanization and industrialization was suddenly having to pay attention to a mechanical clock,” she said. Earlier infant-care manuals had advised feeding a baby when he showed signs of hunger. Now medical advice put infants on feeding schedules as rigid as railway timetables. But, as Wolf pointed out, “to build up a milk supply, you need to put the baby to the breast often, especially in the first few months.” The women complaining that they lacked sufficient milk were not, as one theory had it, suffering from the ill effects of too much education during puberty. Rather, they were following advice unwittingly engineered to fail.  

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"By the nineteen-forties, most mothers were giving birth in hospitals, where orderly routine—babies in nurseries, bottles on schedules—often took priority over the personal attention required to initiate breast-feeding. 

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"Commercial infant formula from brands such as Similac and Enfamil took off in the fifties—a modern amenity that sat comfortably alongside Betty Crocker cake mix and Cheez Whiz. (Formula had also made it easier for women to work outside the home.) At the same time, the decade saw the rise of some of breast-feeding’s most influential evangelists. The La Leche League was founded in 1956 by seven Catholic housewives in the Chicago suburbs who wanted to create a forum for breast-feeding mothers to share questions and advice. La Leche occupied a tricky cultural position, at once radical and conservative: on the one hand, it encouraged women to claim control of their bodies and to defy voices of institutional authority; on the other, the intended result of this rebellion was a world in which a mother’s place was unequivocally at home.

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"Meanwhile, the alternative to breast-feeding—formula—began to take on a sinister light. An industry that had presented itself as a best friend to mid-century mothers showed a different face in its dealings abroad. New reports linked Nestlé’s aggressive marketing of formula to infant deaths in the Global South, making the case that the company’s product had been pushed on families who lacked the resources (such as clean water) to bottle-feed safely. Instead of a scientifically perfected modern convenience, formula became “The Baby Killer,” in the words of one influential pamphlet. A years-long global boycott of Nestlé ensued. In 1981, the World Health Organization adopted a resolution that aimed to ban the promotion of substitutes for breast milk. The U.S. was the only country in opposition. (Today, Nestlé stresses its compliance with W.H.O. code.)

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"products intended to provide complete infant nutrition (that is, formulas) must clear more hurdles than other foods. A new product must, among other things, undergo what are essentially clinical trials, which can involve recruiting hundreds of babies to participate.

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"The distribution of human breast milk has traditionally taken place at nonprofit milk banks, and recent attempts to introduce commerce into this transaction have stirred controversy. In 2014, a company called Medolac, selling shelf-stable human milk, announced that it would expand its milk-bank program in Black communities in Detroit. The plan was scrapped after backlash from community groups and activists, who called out the company for its low pay in comparison with its pricing and for reinforcing historical injustice. (At the time, the company denied allegations of exploitation.) Biomilq seems keen to avoid any impression of similar obliviousness. Egger told me that the company has encouraged employees to read Andrea Freeman’s “Skimmed,” an account of racial inequities perpetrated by the formula industry. And even as Biomilq describes itself as “women-owned” and “mother-centered,” it also notes that “lactation is not only for cisgender biological mothers.” 

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